Adding a certain compound to certain chemical reactions, such as: 1086381-28-3, 4-Bromo-2-cyclopropylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
To a stirred solution of aryl bromide (4.42 mmol) in anhydrous DMF (16 mL) was added ethyl acrylate (5.75 mmol), Pd(OAc)2 (0.44 mmol), DABCO (8.84 mmol) and potassium carbonate (8.84 mmol). The solution was degassed under nitrogen for 15 min before heating to 125C for 17 h. The mixture was cooled, diluted with H2O (30 mL) and extracted into DCM (2 x 30 mL). The organic layers were washed with H2O (3 x 50 mL) and brine (2 x 50 mL), passed through a phase separator and concentrated. Following method D from 4-bromo-2-(cyclopropyl)pyridine (1 .00 g, 5.05 mmol). Purification by flash silica column chromatography (gradient elution /’-hex to 10% EtOAc in /-hex) gave the title compound as a white solid (530 mg, 48%). LCMS (ES+) 218 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1086381-28-3, 4-Bromo-2-cyclopropylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; CHDI FOUNDATION, INC.; LUCKHURST, Christopher A.; HAUGHAN, Alan F.; BRECCIA, Perla; STOTT, Andrew J.; BURLI, Roland W.; HUGHES, Samantha J.; MUNOZ-SANJUAN, Ignacio; DOMINGUEZ, Celia; MANGETTE, John E.; WO2012/103008; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem