As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1201676-03-0, name is 4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one, molecular formula is C7H4Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
4,6-Dichloro-2,3-dihydro-pyrrolo[3,4-c]pyridin-1-one (5.63 g, 27.7 mmol), te/f-butyl piperazine-1-carboxylate (7.75 g, 41.6 mmol), triethylamine (14.Og, 139 mmol), and dioxane (50 ml.) are stirred at 120 0C in a 350 ml. sealed tube for 16 h. To the cooled down reaction mixture are then added more te/f-butyl piperazine-1-carboxylate (5.2 g, 27.7 mmol) and triethylamine (2.83 g, 28.0 mmol). The vessel is sealed again and stirred at 120 0C for 24 h. The reaction mixture is then cooled to ambient temperature, and a light-pink solid is isolated by filtration (6.18 g, 17.5 mmol, 63%). MS(ESI) m/z 353.15 (M+1 ). 1H NMR (400 MHz, DMSOd6) delta ppm 9.04 (s, 1 H), 6.89 (s, 1 H), 4.57 (s, 2 H), 3.61 – 3.54 (m, 4 H), 3.47 – 3.41 (m, 4 H), 1.42 (s, 9 H).D. 4-(4-Chloro-1 -oxo-2,3-dihydro-1 H-pyrrolo[3,4-c]pyridin-6-yl)-piperazine-1 -carboxylic acid terf-butyl ester.
With the rapid development of chemical substances, we look forward to future research findings about 1201676-03-0.
Reference:
Patent; NOVARTIS AG; WO2009/150230; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem