Application of 1180132-17-5, Adding some certain compound to certain chemical reactions, such as: 1180132-17-5, name is 5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine,molecular formula is C12H20N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1180132-17-5.
Add to the reaction flask7- (2-Chloro-5-fluoropyrimidin-4-yl)Fluoro-2,2-dimethyl- dihydro-lH-benzo [d]Pyrrolo [1,2-a]Imidazole (100 mg, 0.3 mmol, prepared as in Example 4)5 – ((4-ethylpiperazin-1-yl)Methyl) pyridin-2-amine (66 mg, 0.3 mmol)Cesium carbonate (195 mg, 0.6 mmol), Pd2 (dba) 3 (27 mg, 0.03 mmol), XantPhos (35 mg, 0.06 mmol) and 1,4-dioxane (2 mL).The mixture was microwave reacted at 150 C for 45 minutes.Cooled to room temperature, water (10 mL) and ethyl acetate (20 mL x 3) were added to the solution.The organic phases were combined, washed with saturated sodium chloride solution (10 mL), dried over anhydrous sodium sulfate,Filtered, concentrated under reduced pressure. The residue was purified by column chromatography (DCM / MeOH = 10: 1)The resulting residue was purified to give the title compound (20 mg, yellow solid) in 14% yield.
According to the analysis of related databases, 1180132-17-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem