Brief introduction of 5-Bromo-2-fluoropyridin-3-ol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1012084-53-5, 5-Bromo-2-fluoropyridin-3-ol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1012084-53-5, 5-Bromo-2-fluoropyridin-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3BrFNO, blongs to pyridine-derivatives compound. Computed Properties of C5H3BrFNO

a)Diisopropylethylamine (0.41 mL, 2.34 mmol) and [2-(chloromethoxy)ethyl](trimethyl) silane (0.32 mL, 1.80 mmol) were added to a solution of 5-bromo-2-fluoropyridin-3-ol (0.30 g, 1.56 mmol) in dichloromethane (8 mL) at 0 C and the resulting mixture was stirred at room temperature for 5 hours. The reaction mixture was partitioned betweendichloromethane and saturated aqueous solution of sodium hydrogencarbonate. The organic layer was separated, washed with brine, dried over magnesium sulfate and the solvent was evaporated to dryness. The resulting crude was purified by flash chromatography (gradient from hexanes to diethyl ether) to yield the title compound(0.31 g, 62%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1012084-53-5, 5-Bromo-2-fluoropyridin-3-ol, and friends who are interested can also refer to it.

Reference:
Patent; ALMIRALL, S.A.; BACH TANA, Jordi; PEREZ CRESPO, Daniel; LLERA SOLDEVILA, Oriol; ESTEVE TRIAS, Cristina; TABOADA MARTINEZ, Lorena; WO2015/86693; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem