Reference of 59105-50-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59105-50-9, name is (5-Bromopyridin-3-yl)(phenyl)methanone, molecular formula is C12H8BrNO, molecular weight is 262.1, as common compound, the synthetic route is as follows.
The 3-bromo-5-benzoyl-pyridine (270 mg, 1 . 0mmol), potassium thioacetic acid (183 mg, 1 . 61mmol) dissolved in dioxane (10 ml), add DIPEA (0.36 ml, 2 . 1mmol), after the replacement Ar gas, adding Pd2(dba)3, (23.8 mg, 0 . 026mmol), Xantphos (30 mg, 0 . 052mmol), Ar gas replacement again 3 times, the temperature is increased to 100 C reflux reaction 10h.The filtrate was washed with ethyl acetate, combined with ethyl acetate and filtrate, evaporated to dryness and the residue was purified by silica gel column chromatography to give an orange-red oil (116 mg, 45%).
Statistics shows that 59105-50-9 is playing an increasingly important role. we look forward to future research findings about (5-Bromopyridin-3-yl)(phenyl)methanone.
Reference:
Patent; Chinese Academy of Sciences, Shanghai Institute of Materia Medica; Nanjing Changao Pharmaceutical Technology Co., LTD; YANG, YU SHE; LING, CHEN YU; FU, LI QIANG; LI, ZHAN; (49 pag.)CN103626693; (2016); B;,
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