Brief introduction of 5-Chloro-1H-pyrrolo[3,2-b]pyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65156-94-7, its application will become more common.

Reference of 65156-94-7 ,Some common heterocyclic compound, 65156-94-7, molecular formula is C7H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

B. 1-Benzenesulfonyl-5-chloro-1H-pyrrolo[3,2-b]pyridine The title compound is prepared from 5-chloro-1H-pyrrolo[3,2-b]pyridine as described in EXAMPLE 41, Part A. The crude product is purified by column chromatography eluding with a gradient of 10% EtOAc/hexanes to 20% EtOAc/hexanes to give the title compound as a solid. 1H NMR (CDCl3, 300 MHz) delta8.23 (d, 1H), 7.87 (d, 2H), 7.81 (d, 1H), 7.62 (m, 1H), 7.49 (m, 2H), 7.26 (d, 1H) 6.81 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65156-94-7, its application will become more common.

Reference:
Patent; Aventis Pharma Deutschland GmbH; US6281227; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem