Adding a certain compound to certain chemical reactions, such as: 80194-69-0, 5-(Trifluoromethyl)picolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 80194-69-0, blongs to pyridine-derivatives compound. Recommanded Product: 80194-69-0
Example 28 N-(3-((2R,5R)-6-amino-3,3,5-trifluoro-2,5-dimethyl-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-5-(trifluoromethyl)picolinamide Prepared from (3R,6R)-6-(5-amino-2-fluorophenyl)-3,5,5-trifluoro-3,6-dimethylpiperidine-2-thione and 5-(trifluoromethyl)picolinic acid LC-MS (m/z) 463 (MH+) tR=0.61 minutes (Method A) 1H NMR (600 MHz, DMSO-d6) delta 10.96 (s, 1H), 9.18-9.09 (m, 1H), 8.48 (dd, J=8.3, 2.1 Hz, 1H), 8.33 (d, J=8.2 Hz, 1H), 7.89-7.81 (m, 2H), 7.17 (dd, J=11.9, 8.7 Hz, 1H), 6.58-6.29 (m, 2H), 2.62-2.52 (m, 1H), 2.31-2.16 (m, 1H), 1.77-1.66 (m, 6H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,80194-69-0, 5-(Trifluoromethyl)picolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; H. LUNDBECK A/S; Juhl, Karsten; Marigo, Mauro; Tagmose, Lena; Jensen, Thomas; US2015/232449; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem