Application of 5470-17-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5470-17-7, name is 3-Bromo-2-chloro-5-nitropyridine, molecular formula is C5H2BrClN2O2, molecular weight is 237.44, as common compound, the synthetic route is as follows.
Example 16: Representative synthesis of Compound 201 Summary Compound 201 was synthesized via a seven-step route depicted below.Scheme: 36Ref: 1) Justus Liebigs Annalen tier Chemie, 1937, 529, 291 Experimental Step 1 To a solution of 3-bromo-2-chloro-5-nitropyridine (23.5g, 100 mmol ) in 200 mL of CH3OH was added CFbONa ( 54g , 1.0 mol ) with stirring in an ice bath. The resulting solution was heated at 80 C for 12 hrs and cooled to room temperature .The reaction mixture was diluted with 200 mL of H20 and extracted with ethyl acetate (3 x 250 mL). The organic phase was dried over magnesium sulfate, filtered and concentrated to give a residue, which was purified by column chromatography over silica gel (50: 1 , petroleum ether/ EtOAc ) to afford a( 6.8 g, 34% ) as a yellow oil.
Statistics shows that 5470-17-7 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-chloro-5-nitropyridine.
Reference:
Patent; GENZYME CORPORATION; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; MAZITSCHEK, Ralph; CLARDY, Jon, C.; WIRTH, Dyann; WIEGAND, Roger; URGAONKAR, Sameer; BANIECKI, Mary, Lynn; CORTESE, Joseph; CELATKA, Cassandra; XIANG, Yibin; SKERLJ, Renato; BOURQUE, Elyse, M.j.; WO2011/53697; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem