Related Products of 55052-27-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55052-27-2, name is 6-Chloro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The title compound of Preparation 57 (1.00 g, 6.55 mmol), 2,4,6-trimethyl-1,3,5,2,4,6-trioxatriborinane (1.0 ml, 7.2 mmol) and potassium carbonate (2.72 g, 19.7 mmol) were suspended in 13 ml dimethoxyethane in a microwave reactor and submitted to three vacuum-argon cycles. [1,1′-Bis(diphenylphosphino)ferrocene]-dichloropalladium (II) complex with dichloromethane (0.29 g, 0.33 mmol) was added and the resulting mixture was submitted to three further vacuum-argon cycles. The mixture was stirred at 120ºC for 2h under microwave irradiation. The mixture was allowed to cool and was filtered through Celite, eluting with ethyl acetate. The filtrate was evaporated under reduced pressure and the residue was purified using the Isolera Purification System (ethyl acetate-hexane gradient, 0:100 rising to 50:50) to give 0.57 g (4.31 mmol, 65%) of the title compound as a beige solid. Purity 98%. [0443] 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 10.87 (br. s., 1 H), 7.86 (d, J=7.63 Hz, 1 H), 7.29 (dd, J=3.52, 2.35 Hz, 1 H), 6.97 (d, J=7.63 Hz, 1 H), 6.47 (dd, J=3.52,1.76 Hz, 1 H), 2.69 (s, 3 H). [0444] HPLC/MS (15 min) retention time 2.57 min. [0445] LRMS:m/z133(M+1).
According to the analysis of related databases, 55052-27-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, Maria Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, Maria Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura; EP2548876; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem