As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid, molecular formula is C7H6N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Methyl-5-nitro-3-pyridinecarboxylic acid
A solution of 2-methyl-5-nitronicotinic acid 1 (50 mg, 0.27 mmol), intermediate II (90 mg, 0.41 mmol), PyBOP (281 mg, 0.54 mmol) and DIEA (0.14 ml, 0.81 mmol) in DCM/DMF (6 ml, 5:1) was stirred at 20C for 16 hr. The mixture was washed with saturated aq. NaHCO3, H2O, dried over MgSO4, and evaporated, and the residue was chromatographed on reverse phase HPLC (10-95% AcN in H2O) to give 3 (92 mg) as a brown solid. (Calculated mass: 365.4, observed mass: 364.6).
With the rapid development of chemical substances, we look forward to future research findings about 59290-81-2.
Reference:
Patent; KEMIA, INC.; WO2007/56016; (2007); A2;,
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