Application of 6515-38-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6515-38-4, name is 3,5,6-Trichloropyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
General procedure: 2-Chloro-4-(trifluoromethyl)phenol (0.43 g, 2.19 mmol) was dissolved in 15 mL of butanone, and anhydrous potassium carbonate (0.60 g, 4.35 mmol) was added to the solution. The solution was stirred for 0.5 h, and methyl (E)-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate (0.63 g, 2.20 mmol) was then added. The reaction mixture was heated to 80 C and monitored by TLC. After five hours, the mixture was cooled, diluted with 50 mL water and extracted with ethyl acetate (3 × 100 mL). The combined extracts were washed with brine, dried (anhydrous magnesium sulfate), and filtered. The filtrate was evaporated and the crude product was purified via silica gel column chromatography, using a 1:2 (v/v) mixture of ethyl acetate and petroleum ether (boiling point range: 60-90 C) as the eluting solution to obtain compound 2b as a white solid: 0.67 g (72.9%), mp 115-116 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6515-38-4, its application will become more common.
Reference:
Article; Li, Lin; Li, Miao; Chi, Huiwei; Yang, Jichun; Li, Zhinian; Liu, Changling; Journal of Fluorine Chemistry; vol. 185; (2016); p. 173 – 180;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem