In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 84539-34-4, name is 4-Amino-3,5-dibromopyridine, the common compound, a new synthetic route is introduced below. SDS of cas: 84539-34-4
Intermediate s:3-bromo-5-{cyclohex-1-en-1-yl)pyridln-4-amine To a stirred and nitrogen degassed solution of 3,5-dibromopyridin-4-amine (CAS 84539-34-4; 2.00 g, 7.94 mmol), potassium carbonate (2.20 g, 15.88 mmol) and (cyclohex-i-en-i-yl)boronic acid (CM 89490-05-1; 1.10 g, 8.73 mmol) in dioxane (26 mL) and water (1.6 mL) was added bis(triphenylphosphine)palladium(1I) dichioride (CAS 13965-03-2; 557 mg, 794 iimol). The reaction mixture was heated under microwave irradiation at 130 C for 1.5 h. The reaction mixture was poured into water and extracted with EtOAc. The combined organics were dried (MgSOJ, filtered and concentrated in vczczw. The crude product was purified by column chromatography (silica, 0-50% EtOAc / petroleum ether) to afford the title compound.?H NMR (400 MHz, DK{SO-d5) 6 ppm i.8 – 1.69 (m, 2 H) 1.69 – 1.78 (m, 2 H) 2.15 (br. S., 4 H) 5.62 – (m, H) 7.78 (s, i H) 8.i6 (s, iH)MS ES: 255
The synthetic route of 84539-34-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA CAMBRIDGE LTD; BARKER, Gregory; DAVENPORT, Richard; DOWNHAM, Robert; FARNABY, William; GOLDBY, Anne; HANNAH, Duncan; HARRISON, David; WILLEMS, Henriette; (390 pag.)WO2015/198045; (2015); A1;,
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