Related Products of 909036-46-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 909036-46-0, name is 2-Chloro-3-iodopyridin-4-amine. A new synthetic method of this compound is introduced below.
10.4 Synthesis of N-(2-chloro-3-iodo-pyridin-4-yl)methanesulfonamide 3a* 2-Chloro-3-iodo-pyridin-4-ylamine 2a* (5.1 g, 20 mmol) and triethylamine (14 mL, 100 mmol) were stirred in DCM (100 mL) and cooled in an ice water bath. Methanesulphonyl chloride (7.7 mL, 100 mmol) was added dropwise and stirred at room temperature for two h. The reaction mixture was washed with water (100 mL), dried over MgSO4 and concentrated in vacuo. The crude product was purified by column chromatography using 1% AcOEt in DCM to yield N-methanesulfonamide-N-(2-chloro-3-iodo-pyridin-4-yl)-methanesulfonamide (4.2 g, 51 %). 1H NMR (400 MHz, DMSO) delta(ppm): 8.53 (1 H, d, J = 5.1 Hz), 7.74 (1 H, d, J = 5.1 Hz), 3.70 (6 H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,909036-46-0, 2-Chloro-3-iodopyridin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel (Prof. Dr.); Falcenberg, Mathias (Dr.); EP2818472; (2014); A1;,
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