Application of 960298-00-4 ,Some common heterocyclic compound, 960298-00-4, molecular formula is C12H10BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2-benzyloxy-4-bromopyridine 6 (201 mg, 0.8 mmol) in MeOH(4.5 mL) was added conc. HCl (2.3 mL). The mixture was heated at reflux overnight.Then the reaction mixture was cooled to room temperature and concentrated underreduced pressure. The residue was poured into cold water and carefully quenchedwith aq. sat. Na2CO3. The aqueous layer was extracted with ethyl acetate (3x). Thecombined organic layers were washed with brine, dried (Na2SO4), filtered andconcentrated under reduced pressure. The crude was purified by flash chromatography on silica gel (EtOAc/MeOH: 98/2) to give 1c (109 mg, 82%) as acolorless solid. Data for 1c are reported above.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,960298-00-4, its application will become more common.
Reference:
Article; Honraedt, Aurelien; Gallagher, Timothy; Synlett; vol. 27; 1; (2016); p. 67 – 69;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem