Application of 1034667-22-5, Adding some certain compound to certain chemical reactions, such as: 1034667-22-5, name is 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine,molecular formula is C6H5FN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1034667-22-5.
Reagents and conditions: (i) HCl, Et2O/MeOH, (ii) NH3, EtOH; (iii) Et3N, EtOH , reflux; (iv) POCl3, reflux; (v) 5-fluoro-lH- pyrazolo [3, 4-b] pyridin-3-amine, DIPEA, NaI, DMF, 1200C.[0052] Scheme I above shows a general synthetic route that is used for preparing the compounds 1-5. Compounds of formula 1-5 can be prepared from intermediate I-l. The formation of amidine 1-2 is achieved by treating nitrile derivative I-l with HCl in the presence of methanol and then treating the intermediate imidate with NH3 in ethanol. Intermediate 1-2 is then treated with the corresponding beta-ketoester via reflux in EtOH. The corresponding hydroxypyrimidine intermediate is treated with POCl3 to yield chloroderivative 1-4. This reaction is amenable to a variety of amidines (1-3) . The chloropyrimidine 1-4 is treated with 5-fluoro-lH-pyrazolo [3, 4-b] pyridin-3-amine in the presence of DIPEA and NaI to yield the final compound 1-5.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1034667-22-5, 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2009/18415; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem