Synthetic Route of 139022-25-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 139022-25-6, name is Imidazo[1,2-a]pyridine-6-carboxylic acid. A new synthetic method of this compound is introduced below.
A suspension of imidazo[1,2-a]pyridine-6-carboxylic acid (1.0 g), EDCI (1.775 g), HOBt (1.415 g) and N-methylmorpholine (1.0 ml) in DMF (20 ml) and DCM (5 ml) was stirred at 22C for 40 min. The resulting reddish solution was treated with diisopentylamine (1.9 ml) and N-methylmorpholine (1.0 ml) in this order and the reaction mixture was stirred at 22C for 24 h. The mixture was diluted with diethyl ether (100 ml) and washed with saturated sodium bicarbonate solution (2 x 60 ml). The combined aqueous layer was washed with diethyl ether (2 x 50 ml). The combined organic extract was washed with water (100 ml) and brine (100 ml), dried over sodium sulfate, filtered, and evaporated. The crude product was purified by column chromatography.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,139022-25-6, Imidazo[1,2-a]pyridine-6-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2168965; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem