Electric Literature of 185041-05-8 ,Some common heterocyclic compound, 185041-05-8, molecular formula is C7H5ClINO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[00324] To a solution of compound 13 (5.5 g, 18.5 mmol) in DMF (50 mL) was added K2C03 (10.2 g, 74 mmol), trimethylboroxine (4.64 g, 3.70 mmol) and Pd(PPh3)4 (2.1 g, 1.85 mmol) in DMF under N2. The reaction mixture was stirred at 110 C for 120 mm under N2. After cooled down, water (100 mL) was added into the mixture. Et20 was added to extract the product, washed by water and dried over Na2SO4 .Concentrated and purified by FCC (PE/EA=40: 1) to afford 2.7 g of the product 14 (79%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 185041-05-8, Methyl 2-chloro-4-iodonicotinate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; YANG, Wenjin; CHEN, Che-Hong; MOCHLY-ROSEN, Daria; WO2014/160185; (2014); A2;,
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