Reference of 59942-87-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59942-87-9, name is Pyrazolo[1,5-a]pyridin-2(1H)-one, molecular formula is C7H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of pyrazolo[1,5-a]pyridin-2-ol (776 mg, 5.78 mmol), K2CO3 (2.4 g, 17.3 mmol), 1-bromo-4-chlorobutane (1.35 mL, 11.6 mmol) and sodium iodide (catalytic amount) in 20 mL of DMF was stirred for 18 h at room temperature. The resulting mixture was filtered, the solid washed with DMF and the organic filtrate concentrated. The residue was poured into diethyl ether and the generated precipitate filtered and discarded. The organic filtrate was washed with water and the organic layer dried (Na2SO4) and concentrated under vacuum to afford 1.35 g (quantitative) of brown oil.
According to the analysis of related databases, 59942-87-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; Diaz-Fernandez,Jose-Luis; Cuberes-Altisent,Mª Rosa; EP2631236; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem