Adding a certain compound to certain chemical reactions, such as: 183741-80-2, tert-Butyl (6-methoxypyridin-3-yl)carbamate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 183741-80-2, blongs to pyridine-derivatives compound. Formula: C11H16N2O3
[0614] Procedure: To a stirred solution of tert-butyl (6-methoxypyridin-3-yl)carbamate (7 g, 31.231 mmol) and tetramethylethylenediamine (14.05 mL , 93.640 mmol) in ether (140 mL) was added n-BuLi (46.82 mL, 3 eq, 2M solution in cyclohexane) at -78 C and the mixture was stirred at-10 C for 3 h. After re-cooling to- 78 C, dry carbon dioxide gas was bubbled and stirred for 5 min. The resulting suspension was allowed to room temperature and diluted with water. Organic layer separated and washed with dil. ammonium hydroxide solution. The combined aq. layer was acidified to pH 6 with dil. HCl. The resulting precipitate was filtered, dried under vacuum to afford 5-((tert-butoxycarbonyl)amino)-2-methoxyisonicotinic acid as off white solid (7.2 g, 85.99 %).1HNMR (400 MHz, DMSO-d6): delta 9.37 (bs, 1H), 8.67 (s, 1H), 7.11-(s, 1H), 3.84 (s, 3H), 1.44 (s, 9H). LC-MS (ES) m/z = 269.1 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183741-80-2, its application will become more common.
Reference:
Patent; MAVUPHARMA, INC.; GALLATIN, William Michael; ODINGO, Joshua; DIETSCH, Gregory N.; FLORIO, Vincent; VENKATESHAPPA, Chandregowda; DURAISWAMY, Athisayamani Jeyaraj; (273 pag.)WO2019/46778; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem