Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP) was written by Brittain, William D. G.;Cobb, Steven L.. And the article was included in Organic Letters in 2021.Safety of 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
The present work describes the application of pentafluoropyridine (PFP), a cheap com. available reagent, in the deoxyfluorination of carboxylic acids RC(O)OH (R = Et, adamantan-1-yl, Ph, 2-iodophenyl, etc.) to acyl fluorides RC(O)F. The acyl fluorides can be formed from a range of acids under mild conditions. The PFP that can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides was also demonstrated. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides RC(O)N(R1)R2 (R1 = H, Me, Et; R2 = Et, Ph, 3-nitrophenyl, etc.) in yields of 鈮?4%. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Safety of 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2,3,4,5,6-Perfluoropyridine