The Dimroth rearrangement. IV. A study of facilitation by electron-withdrawal. Alkylated 2-alkyliminopyrimidines was written by Brown, D. J.;Harper, J. S.. And the article was included in Journal of the Chemical Society in 1965.Recommanded Product: 4088-62-4 The following contents are mentioned in the article:
cf. CA 63, 7006d. The rates of Dimroth rearrangement of nuclear N-methylated 2-and 4-iminopyrimidines are increased by the electron-withdrawal provided by a 5-bromo substituent, and much more by the greater electron-attracting power of a 5-nitro group. 1-Benzyl-1,2-dihydro-2-methyliminopyrimidine largely rearranges into 2-benzylimino-1,2-dihydro-1-methylpyrimidine, but the reverse reaction is not detectable by ultraviolet spectral means. Unlike the pyrimidine analogs, 1,2-dihydro-2-imino-1-methylpyridine and its 5-chloro-, 3,5-dichloro-, and 5-cyano derivatives do not rearrange. Only in its 3- and 5-nitro derivatives is there sufficient localization of 蟺-electrons to permit easy rearrangement. This study involved multiple reactions and reactants, such as 3,5-Dichloro-N-methylpyridin-2-amine (cas: 4088-62-4Recommanded Product: 4088-62-4).
3,5-Dichloro-N-methylpyridin-2-amine (cas: 4088-62-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 4088-62-4