Buettelmann, Bernd; Alanine, Alexander; Bourson, Anne; Gill, Ramanjit; Heitz, Marie-Paule; Mutel, Vincent; Pinard, Emmanuel; Trube, Gerhard; Wyler, Rene published the artcile< 2-Styrylpyridines and 2-(3,4-dihydro-naphthalen-2-yl)pyridines as potent NR1/2B subtype selective NMDA receptor antagonists>, Application of C6H7BrN2, the main research area is styryl pyridine preparation NMDA receptor antagonist SAR; structure activity relationship NMDA receptor antagonist styryl pyridine; naphthalenyl pyridine preparation NMDA receptor antagonist SAR.
A series of 2-styryl-pyridines, e.g. I, and 2-(3,4-dihydro-naphthalen-2-yl)pyridines, e.g. II, was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. α1 and M1 receptors) and are active in vivo.
Chimia published new progress about NMDA receptor antagonists. 79055-59-7 belongs to class pyridine-derivatives, and the molecular formula is C6H7BrN2, Application of C6H7BrN2.