From Pyridine-N-oxides to 2-Functionalized Pyridines through Pyridyl Phosphonium Salts: An Umpolung Strategy was written by Bugaenko, Dmitry I.;Yurovskaya, Marina A.;Karchava, Alexander V.. And the article was included in Organic Letters in 2021.HPLC of Formula: 59718-84-2 This article mentions the following:
The reactions of pyridine-N-oxides with Ph3P under the developed conditions provide an unprecedented route to (pyridine-2-yl)phosphonium salts. Upon activation with DABCO, these salts readily serve as functionalized 2-pyridyl nucleophile equivalent This umpolung strategy allows for the selective C2 functionalization of the pyridine ring with electrophiles, avoiding the generation and use of unstable organometallic reagents. The protocol operated at ambient temperature and tolerated sensitive functional groups, enabling the synthesis of otherwise challenging compounds In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2HPLC of Formula: 59718-84-2).
Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 59718-84-2