Bukhari, Syed Majid Hanif; Khan, Samiullah; Rehanullah, Muhammad; Ranjha, Nazar Mohammad published an article in 2015, the title of the article was Synthesis and characterization of chemically cross-linked acrylic acid/gelatin hydrogels: effect of pH and composition on swelling and drug release.Category: pyridine-derivatives And the article contains the following content:
This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as crosslinking agent, resp. Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of crosslinking on swelling and release pattern of the model drug.The swelling behavior of the hydrogel samples was studied in 0.05M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5.The prepared samples were evaluated for porosity and sol-gel fraction anal. Pheniraminemaleate used for allergy treatment was loaded as model drug in selected samples. The release study of the drug was investigated in 0.05M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 h. The release data was fitted to various kinetic models to study the release mechanism. Hydrogels were characterized by Fourier transformed IR (FTIR) spectroscopy which confirmed formation of structure. Surface morphol. of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives
The Article related to acrylic acid gelatin hydrogel drug delivery system, Pharmaceuticals: Formulation and Compounding and other aspects.Category: pyridine-derivatives