Buttelmann, Bernd; Alanine, Alexander; Bourson, Anne; Gill, Ramanjit; Heitz, Marie-Paule; Mutel, Vincent; Pinard, Emmanuel; Trube, Gerhard; Wyler, Rene published the artcile< 2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists>, Related Products of 79055-59-7, the main research area is NMDA receptor antagonist structure activity relationship design.
Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogs. The SAR developed in this series resulted in the discovery of high affinity antagonists which are selective (vs α1 and M1 receptors) and active in vivo.
Bioorganic & Medicinal Chemistry Letters published new progress about Drug design. 79055-59-7 belongs to class pyridine-derivatives, and the molecular formula is C6H7BrN2, Related Products of 79055-59-7.