Synthesis, Antiproliferative and Pro-Apoptotic Effects of Nitrostyrenes and Related Compounds in Burkitt′;s Lymphoma was written by Byrne, Andrew J.;Bright, Sandra A.;Fayne, Darren;McKeown, James P.;McCabe, Thomas;Twamley, Brendan;Williams, Clive;Meegan, Mary J.. And the article was included in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2018.Application In Synthesis of Pyridinehydrochloride This article mentions the following:
Background: Cancers of the lymphatic cells (lymphomas) account for approx. 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt′s lymphoma (BL). Objectives: The aims of the curent study were to synthesize a panel of nitrostyrene compounds and to evaluate their activity in Burkitt′s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesized using Henry Knoevenagel condensation reactions. Single crystal X-Ray anal. confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG- 75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, resp., in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt′s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt′s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Pyridinehydrochloride