Cai, Pengfei; Gao, Zhan; Yin, Xinchi; Luo, Yuanqing; Zhao, Xiaoyong; Pan, Yuanjiang published the artcile< facile enantioseparation and recognition of mandelic acid and its derivatives in self-assembly interaction with chiral ionic liquids>, Synthetic Route of 3796-23-4, the main research area is enantioseparation mandelic acid derivatives self assembly chiral ionic liquids; chiral separation; coprecipitation; ionic liquids; mandelic acid.
Mandelic acid and its derivatives are important medical intermediates in the pharmaceutical industry. Different stereoisomers exhibited distinct biol. properties to human bodies. Given that, enantioselective recognition and separation of mandelic acid are of great importance. In this study, four novel different types of chiral ionic liquids bearing designed functional groups were synthesized and successful enantioselective precipitation with mandelic acid and its derivatives That is, (R, R)-chiral ionic liquid 1 can coprecipitated with S-mandelic acid and its derivatives was observed In addition, good correlation coefficient is achieved by using electrospray mass spectrum at neg. ion pattern for quick anal. of the enantioselective precipitation, which could be served as a method of enantioselective recognition. The possible intermol. interactions are established after systematical studies by NMR spectroscopy and DFT calculations
Journal of Separation Science published new progress about Chiral resolution. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Synthetic Route of 3796-23-4.