Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 198904-85-7, 198904-85-7, Name is tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate, molecular formula is C17H21N3O2, belongs to pyridine-derivatives compound. In a document, author is Zhao, Xinyun, introduce the new discover.
Regioselective synthesis of 2-and 4-diarylpyridine ethers and their inhibitory activities against phosphodiesterase 4B
Two diaryl ether regioisomers of pyridine were prepared through the CuI/TMEDA/Cs2CO3-catalyzed reaction of 2,4-dibromopyridine with phenol derivatives under nitrogen atmosphere. The polar solvent DMSO gave 4-isomer as the major product whereas less polar toluene resulted in 2-isomer as a major product. Structures of regioisomers were confirmed by single crystal X-ray diffraction analysis. 4-regioisomer shows higher biological activity against phosphodiesterase 4B (PDE4B) than that of 2-isomer. Molecular docking simulations revealed that the PDE4B-inhibitory activity difference between the two regioisomers was mainly attributed to the atomic charge difference on the -O- linker. (C) 2019 Elsevier B.V. All rights reserved.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 198904-85-7. Recommanded Product: 198904-85-7.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem