Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2402-78-0, Name is 2,6-Dichloropyridine, SMILES is ClC1=CC=CC(Cl)=N1, belongs to pyridine-derivatives compound. In a document, author is Senthilkumar, Thangaraj, introduce the new discover, SDS of cas: 2402-78-0.
Conjugated Polymer Nanogel Binding Anticancer Drug through Hydrogen Bonds for Sustainable Drug Delivery
Hydrogen-bonded drug conjugation is highly expected as the next-generation smart therapeutic agent that remains stable in biological medium. A carrier design strategy of hydrogen-bonded drug conjugates as pendants in conjugated polymer nanogel is developed. The H-bond acceptor uracil-functionalized poly(p-phenylenevinylene) and 2, 6-diamino pyridine ( H-bond donor)-functionalized doxorubicin (Dox-Py) are synthesized. Further, chemically cross-linked PPV-nanogel with hydrogen-bonded drug complex (PPV-NG/Dox-Py) is fabricated. The presence of triple-point hydrogen bonding in polymer complex as well as in nanogel network is confirmed by H-1 NMR and FT-IR. The hydrophobic microenvironment offered by conjugated polymers backbone stabilizes the hydrogen bonding in the nanogel network. PPV-nanogel/Dox-Py hydrogen-bonded conjugation facilitates higher drug-loading efficiency (82%) and cancer- cell-killing efficiency than encapsulated drug, indicating the superiority of the present design. Sustainable release of Dox-Py is achieved for several days in response to the redox intracellular and acidic environment inside the cancer cells. The proposed hydrogen bond conjugation strategy could provide a broad platform for developing high-value nanotherapeutics.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2402-78-0 is helpful to your research. SDS of cas: 2402-78-0.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem