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Sun, Mingming; Sheng, Hao; Wu, Tingfeng; Song, Jiaqi; Sun, Huanran; Wang, Yingzhi; Wang, Jiyan; Li, Zhen; Zhao, Huifang; Tan, Junzhen; Li, Yanping; Chen, Guo; Huang, Qingrong; Zhang, Yuan; Lan, Bei; Liu, Shuangping; Shan, Changliang; Zhang, Shuai published the article 《PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3》. Keywords: glioblastoma G6PD PIKE A STAT3 phosphorylation; Fyn; G6PD; Glioblastoma; PIKE-A; Phosphorylation; STAT3.They researched the compound: 6-Aminonicotinamide( cas:329-89-5 ).Electric Literature of C6H7N3O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:329-89-5) here.

Reprogramming of energy metabolism is a hallmark of cancer, and the pentose phosphate pathway (PPP) is a major glucose metabolic pathway important for meeting the cellular demands of biosynthesis and anti-oxidant defense. Our previous study showed that phosphoinositide 3-kinase enhancer-activating Akt (PIKE-A) plays an important role in glioblastoma cell survival and growth under cellular energy stress condition. However, the crucial functions of PIKE-A in cancer energy metabolism are poorly understood. In the present study, we show that PIKE-A promotes DNA biosynthesis, NADPH production and inhibits reactive oxygen species (ROS) production, leading to increasing proliferation and growth of glioblastoma cell and suppressing cellular senescence. Mechanistically, PIKE-A binds to STAT3 and stimulates its phosphorylation mediated by tyrosine kinase Fyn, which enhances transcription of the rate-limitting enzyme glucose-6-phosphate dehydrogenase (G6PD) in the PPP. Finally, targeting PIKE-A-G6PD axis sensitizes glioblastoma to temozolomide (TMZ) treatment. This study reveals that STAT3 is a novel binding partner of PIKE-A which recruits Fyn to phosphorylate STAT3, contributing to the expression of G6PD, leading to promoting tumor growth and suppressing cellular senescence. Thus, the PIKE-A/STAT3/G6PD axis strongly links the PPP to carcinogenesis and may become a promising cancer therapeutic target.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem