Mild regioselective halogenation of activated pyridines with N-bromosuccinimide was written by Canibano, Victoria;Rodriguez, Justo F.;Santos, Mercedes;Sanz-Tejedor, Ascension;Carreno, M. Carmen;Gonzalez, Gema;Garcia-Ruano, Jose L.. And the article was included in Synthesis in 2001.COA of Formula: C5H3Br2NO This article mentions the following:
The regioselective monohalogenation and dihalogenation of pyridines as well as 2,6-dimethoxypyridine with N-bromosuccinimide in different solvents were studied. Reactivity of the substrates decreases in the order amino>hydroxy>methoxy and regioselectivity depends on the position of the substituent (2-substituted > 3-substituted). In most of the cases we obtained monobrominated derivatives regioselectively and in high yields. Hydroxy and amino pyridines can also be dibrominated in almost quant. yield with 2 equiv of NBS. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1COA of Formula: C5H3Br2NO).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C5H3Br2NO