Light-driven transition-metal-free direct decarbonylation of unstrained diaryl ketones via a dual C-C bond cleavage was written by Cao, Dawei;Ataya, Mohamad;Chen, Zhangpei;Zeng, Huiying;Peng, Yong;Khaliullin, Rustam Z.;Li, Chao-Jun. And the article was included in Nature Communications in 2022.Application of 91-02-1 This article mentions the following:
An efficient light-driven transition-metal-free strategy for decarbonylation of unstrained diaryl ketones R1C(O)R2 (R1 = Ph, 2H-1,3-benzodioxol-5-yl, thiophen-2-yl, etc.; R2 = Ph, 4-methoxyphenyl, pyridin-2-yl, etc.) to construct biaryl compounds R1R2 through dual inert C – C bonds cleavage was reported. This reaction featured mild reaction conditions, easy-to-handle reactants and reagents, and excellent functional groups tolerance. The mechanistic investigation and DFT calculation suggest that this strategy proceeds through the formation of dioxy radical intermediate via a single-electron-transfer (SET) process between photo-excited diaryl ketone and DBU mediated by DMSO, followed by removal of CO2 to construct biaryl compounds In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application of 91-02-1).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 91-02-1