Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach was written by Cardinale, Luana;Konev, Mikhail O.;Jacobi von Wangelin, Axel. And the article was included in Chemistry – A European Journal in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:
Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-mol., carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. A photoredox-catalyzed protocol for alkene carbamoylations has been reported. Readily accessible 4-carboxamido-Hantzsch esters I (R1R2 = -(CH2)2O(CH2)2-, -(CH2)5-, Ph, cyclopropane, etc.) serve as convenient starting materials that generate carbamoyl radicals R1N(R2)C(O)CH(R3)CH(R4)(R5)(R3 = 4-cyanophenyl, cyclohexyl, pyridin-3-yl, thiophen-2-yl, etc.; R4 = CN, 4-methylphenyl, pyridin-2-yl, etc.; R5 = SO2C6H5, CN, Ph, 4-methylphenyl, 4-chlorophenyl; R4R5 = 1,3-dioxo-2,3-dihydro-1H-inden-2-yl, 1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-yl, 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl) upon visible light-mediated single-electron transfer. Addition to various alkenes R3CH=C(R4)(R5) proceeded with high levels of regio- and chemoselectivity. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of Phenyl(pyridin-2-yl)methanone