Carson, Matthew W.; Giese, Matthew W.; Coghlan, Michael J. published the artcile< An Intra/Intermolecular Suzuki Sequence to Benzopyridyloxepines Containing Geometrically Pure Exocyclic Tetrasubstituted Alkenes>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is bromopyridine alkyne pinacolatodiboron stereoselective diboration; aryloxy bromopyridine vinylpinacol boronic ester intramol Suzuki coupling palladium; benzopyridyloxepine dioxaborolanylethylidene iodoarene Suzuki coupling palladium; benzylidenyl benzopyridyloxepine derivative preparation; palladium Suzuki couplibng catalyst.
A route to enable the preparation of 5-benzylidenyl-benzopyridyloxepine analogs, e.g., I (R1 = Me, Et, i-Pr; R2 = H, F, MeO), was developed to continue our research in the field of nuclear hormone receptor modulators. The key steps are: 1. a syn-stereoselective diboration of a tethered aryl alkyne; 2. an intramol. Suzuki cross-coupling reaction, which forms in a stereo- and regiocontrolled fashion, the 5-exoalkylidenyl 7-membered ring imbedded within the core of the scaffold and; 3. an intermol. Suzuki to furnish the final tetra-substituted olefinic benzopyridyloxepines.
Organic Letters published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (pyridylmethyl). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.