Reference of 3-Cyanopyridine《Recyclable and Reusable Pd(OAc)2/XPhos-SO3Na/PEG-400/H2O System for Cyanation of Aryl Chlorides with Potassium Ferrocyanide》 was published in 2022. The authors were Cai, Mingzhong;Liu, Rong;Xu, Caifeng;Huang, Bin, and the article was included in《Catalysis Letters》. The author mentioned the following in the article:
Pd(OAc)2/XPhos-SO3Na in a mixture of poly(ethylene glycol) (PEG-400) and water is shown to be a highly efficient catalyst for the cyanation of aryl chlorides with potassium ferrocyanide. The reaction proceeded smoothly at 100 or 120°C with K2CO3 or KOAc as base, delivering a variety of aromatic nitriles in good to excellent yields. The isolation of the crude products is facilely performed by extraction with cyclohexane and more importantly, both expensive Pd(OAc)2 and XPhos-SO3Na in PEG-400/H2O system could be easily recycled and reused at least six times without any apparent loss of catalytic efficiency. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Reference of 3-Cyanopyridine This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.