Kim, Hyeongsu;Xuan, Zi;Hyun Kim, Ju published 《Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles》 in 2021. The article was appeared in 《Chemistry – An Asian Journal》. They have made some progress in their research.Formula: C6H4N2 The article mentions the following:
An efficient tandem route to obtain tetrasubstituted NH pyrroles I (R = Me, Et, Bn; Ar = Ph, 2-naphthyl, pyridin-3-yl, etc.) in a one-pot manner has been developed, staring from simple nitriles ArCN, Et bromoacetates BrCH2CO2R, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles I in yields up to 91%. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Formula: C6H4N2