Mougeot, Romain;Oger, Samuel;Auvray, Marie;Gallavardin, Thibault;Leleu, Stephane;Mahuteau-Betzer, Florence;Franck, Xavier published 《Convergent and Practical Synthesis of Fluorescent Triphenylamine Derivatives and Their Localization in Living Cells》 in 2022. The article was appeared in 《European Journal of Organic Chemistry》. They have made some progress in their research.Application of 100-54-9 The article mentions the following:
In the search for new fluorescent triphenylamine (TP) derivatives, authors studied the influence of the position and substitution of diverse heterocyclic substituents. A library of 10 fluorescent triphenylamines bearing either oxazoles or thiazoles and pyridiniums, substituted at different positions has been developed. The approach is based on a convergent C-H activation reaction between pyridine-oxazoles or pyridine-thiazoles and di-iodo triphenylamine. Author’s showed that the nature and substitution pattern of the 5-membered- (oxazole, thiazole) or 6-membered heterocycle (pyridine) has a strong influence on their fluorescence properties and on their localization in living cells as they stain either the nucleus or mitochondria. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .
3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Application of 100-54-9