Electric Literature of C6H4N2《Switching Selectivity in Copper-Catalyzed Transfer Hydrogenation of Nitriles to Primary Amine-Boranes and Secondary Amines under Mild Conditions》 was published in 2022. The authors were Song, Hao;Xiao, Yao;Zhang, Zhuohua;Xiong, Wanjin;Wang, Ren;Guo, Liangcheng;Zhou, Taigang, and the article was included in《Journal of Organic Chemistry》. The author mentioned the following in the article:
A simple and efficient copper-catalyzed selective transfer hydrogenation of nitriles to primary amine-boranes I [R = n-Bu, Ph, cyclohexyl, etc.] and secondary amines R1CH(R2)NHCH2R3 [R1 = Ph, 2-furyl, 1-naphthyl, etc.; R2 = H, Me; R3 = Ph, 4-MeC6H4, 3-thienyl, etc.] with an oxazaborolidine-BH3 complex was reported. The selectivity control was achieved under mild conditions by switching the solvent and the copper catalysts. More than 30 primary amine-boranes and 40 secondary amines were synthesized via this strategy in high selectivity and yields of up to 95%. The strategy was applied to the synthesis of 15N labeled in 89% yield.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.
3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Electric Literature of C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.