Markovic, Tim;Rocke, Benjamin N.;Blakemore, David C.;Mascitti, Vincent;Willis, Michael C. published 《Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides》. The research results were published in《Chemical Science》 in 2017.Recommanded Product: 2098851-48-8 The article conveys some information:
An efficient procedure was reported for the synthesis of aryl pyridines via Pd-catalyzed desulfinylative cross-coupling of pyridine sulfinates and aryl halides. In addition, these pyridine sulfinates were applied in a library format to the preparation of medicinally relevant derivatives, (6S,10R)-2-(aryl)-7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxalines, I [R = 6-MeO-pyridin-3-yl, 3-pyridyl, 5-Cl-pyridin-2-yl, etc.] of the drug varenicline and N’-(2,2′-biaryl)-N’-(4-methoxybenzyl)-N,N-dimethylethane-1,2-diamines, e.g., II of the drug mepyramine.Sodium 5-(trifluoromethyl)pyridine-2-sulfinate (cas: 2098851-48-8) were involved in the experimental procedure.
N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So Sodium 5-(trifluoromethyl)pyridine-2-sulfinate(cas: C6H3F3NNaO2S) can also undergo this reaction.Recommanded Product: 2098851-48-8