Synthetic Route of C10H9ClN4O2SIn 2021, Ivanov, Evgeniy V. published 《A negative partial volume of methanol in aqueous solutions: How plausible is it? Some comments on “Intermolecular interactions between methanol and some sulphonamide drugs in aqueous medium using thermodynamics approach” by indra Bahadur et al. [J. Mol. Liquid 283 (2019) 451-461]》. 《Journal of Molecular Liquids》published the findings. The article contains the following contents:
The authors of the above paper came recently to the inference that the apparent (down to infinite dilution) molar volumes of methanol in water and aqueous sulfonamides are neg. in sign and unusually large in magnitude. In this regard, two main points relating to the given “phenomenon” were considered here: how plausible is it and what exptl. “features” did the authors apply to achieve such a result. Based on the recalculated authors data and reliable literature data of interest, it is concluded here on the scientific absurdity of results reported in the paper being commented. The main reasons for this could be the sloppy performing exptl. procedures as well as the incorrect using well-known thermodn. relations by the authors (Bahadur et al.). To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .
4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.