Category: 100-26-5

Related Products of 100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

1) Pyridine-2,5-dicarboxylic acid dibenzyl ester Thionyl chloride (250 mL) and N, N-dimethylformamide (10 mL) were added to a solution of 2, 5-pyridinedicarboxylic acid (60 g) in dichloromethane (360 mL), and the resultant mixture was heated to reflux for 5 hours. After air cooling, the solvent of the reaction solution was evaporated under reduced pressure, and toluene was added to the residue thus obtained. The resultant mixture was further azeotropically evaporated under reduced pressure, and a residue thus obtained was dissolved in dichloromethane (500 mL). A solution of benzyl alcohol (81.7 mL) in dichloromethane (200 mL) was added dropwise to the solution at 0C, and the mixture was stirred at room temperature for 4 hours. Water was added to the reaction solution, and the mixture was partitioned. The organic layer was washed with a saturated aqueous solution of sodiumhydrogen carbonate, and then was dried over anhydrous sodium sulfate. After separating the organic layer by filtration, the solvent was evaporated under reduced pressure, to obtain pyridine-2,5-dicarboxylic acid dibenzyl ester (65 g, 52%) as a solid. 1H-NMR (400MHz, CDCl3) delta: 5.42 (2H, s), 5.47 (2H, s), 7.38-7.46 (10H, m), 8.19 (1H, d, J=8.3Hz), 8.44 (1H, dd, J=8.2, 2.1Hz), 9.35-9.36 (1H, m).

According to the analysis of related databases, 100-26-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1803719; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

1) Pyridine-2,5-dicarboxylic acid dibenzyl ester Thionyl chloride (250 mL) and N, N-dimethylformamide (10 mL) were added to a solution of 2, 5-pyridinedicarboxylic acid (60 g) in dichloromethane (360 mL), and the resultant mixture was heated to reflux for 5 hours. After air cooling, the solvent of the reaction solution was evaporated under reduced pressure, and toluene was added to the residue thus obtained. The resultant mixture was further azeotropically evaporated under reduced pressure, and a residue thus obtained was dissolved in dichloromethane (500 mL). A solution of benzyl alcohol (81.7 mL) in dichloromethane (200 mL) was added dropwise to the solution at 0C, and the mixture was stirred at room temperature for 4 hours. Water was added to the reaction solution, and the mixture was partitioned. The organic layer was washed with a saturated aqueous solution of sodiumhydrogen carbonate, and then was dried over anhydrous sodium sulfate. After separating the organic layer by filtration, the solvent was evaporated under reduced pressure, to obtain pyridine-2,5-dicarboxylic acid dibenzyl ester (65 g, 52%) as a solid. 1H-NMR (400MHz, CDCl3) delta: 5.42 (2H, s), 5.47 (2H, s), 7.38-7.46 (10H, m), 8.19 (1H, d, J=8.3Hz), 8.44 (1H, dd, J=8.2, 2.1Hz), 9.35-9.36 (1H, m).

According to the analysis of related databases, 100-26-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1803719; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,5-Pyridinedicarboxylic acid

To a mixture containing Cu(ClO4)2·6H2O (0.190 g, 0.5 mmol) and tris(3-aminopropyl)amine, trpn (0.0.094 g, 0.5 mmol) dissolved in MeOH (20 mL), an aqueous solution (5 mL) of pyridine-2,5-dicarboxylic acid disodium salt (0.053 g, 0.25 mmol) was added. The solution was then heated on a steam-bath for 10 min, filtered through celite and the resulting blue solution was allowed to stand at room temperature. The crude solid, which separated was collected by filtration. Crystallization of the product from H2O afforded tiny blue crystals suitable for X-ray analysis. These were collected by filtration, washed by propan-2-ol, Et2O and dried in air (overall yield: 0.150 g, 82% based on Cu(ClO4)2·6H2O). Characterization: C32H54Cl2Cu3N10O16 (1096.37 g/mol): Calcd: C, 35.06; H, 4.96; N, 12.78. Found: C, 34.88; H, 5.01; N,12.63%. Selected IR bands (ATR, cm1): 3323 (m), 3285 (m) nu(NeH) stretching; 2934 (w), 2889 (w) nu(CeH) stretching; 1594 (s), 1436 (vs)[nu(C]O+C]C+C]N)]; 1070 (vs, b) nu(CleO). UV-Vis (H2O): lambdamax, nm (epsilonmax M-1 cm-1 per Cu atom)=562 (sh), 679 (85), 906 (sh).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Louka, Febee R.; Haq, Sabriah J.; Guidry, Hollie R.; Williams, Bailey R.; Henary, Maher M.; Fischer, Roland C.; Torvisco, Ana; Massoud, Salah S.; Mautner, Franz A.; Inorganica Chimica Acta; vol. 500; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,5-Pyridinedicarboxylic acid

General procedure: Synthesis of methyl ester derivatives of M6, M7, and M17 was carried out under catalytic esterification conditions as depicted in Scheme 1. To a solution of the appropriate carboxylic acid in methanol few drops of conc. sulfuric acid were added. Subsequently, the reaction mixture was refluxed for 6-10 h. After completion, the volatile solvents were evaporated under reduced pressure and the residue was dissolved in water/ethyl acetate mixture. The aqueous phase was extracted with ethyl acetate and the combined organic phase was washed with 5% sodium bicarbonate, brine, and was dried over anhydrous sodium sulfate. After filtration the desired ester was obtained using flash column chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Luniwal, Amarjit; Wang, Lin; Pavlovsky, Alexander; Erhardt, Paul W.; Viola, Ronald E.; Bioorganic and Medicinal Chemistry; vol. 20; 9; (2012); p. 2950 – 2956;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2,5-Pyridinedicarboxylic acid

A mixture of TbCl3·6H2O (0.0373 g, 0.10 mmol), CuCl2·2H2O (0.0171 g, 0.10 mmol), H2pydc (0.0419 g, 0.25 mmol), NaOH (0.0020 g, 0.50 mmol), and H2O (6 mL) was sealed in a 10-mL Teflon-lined stainless steel container and heated at 170 C for 3 day. Upon being cooled to room temperature at a rate of 5 C/h, dark-blue block crystals were obtained in 43% yield (based on Cu). Anal. for C42H50N6O40Cu3Tb2 (%): C, 28.22; H, 2.82; N, 4.70. Found: C, 28.33; H, 2.74; N, 4.77. IR (solid KBr pellet, cm-1): 3399(m), 1638(s), 1610(s), 1554(s), 1456(m), 1394(s), 1352(s), 1276(m), 1171(w), 1150(w), 1039(w), 892(w), 823(m), 767(m), 691(m), 670(m), 510(m), 454(w).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Xia, Zheng-Qiang; Wei, Qing; Chen, San-Ping; Feng, Xin-Ming; Xie, Gang; Qiao, Cheng-Fang; Gao, Sheng-Li; Zhang, Guo-Chun; Journal of Solid State Chemistry; vol. 197; (2013); p. 489 – 498,10;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 100-26-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-26-5 as follows.

A mixture of Bi(NO3)3·5H2O (0.242 g, 0.5 mmol) or Bi2O3 (0.232 g, 0.5 mmol) and pyridine-2, 5-dicarboxylic acid (H2pydc) (0.250 g, 1.5 mmol) in H2O (25 ml) was sealed in a Teflon-lined autoclave and heated to a temperature of 180 C for 3 day, and then cooled slowly at 0.1 C/min to room temperature. Colorless, needle-like crystals were obtained in 90% yield (based on bismuth) admixed with an unidentified white powder phase, which was almost completely separated from the needle shaped crystals by sieving. The products were washed with DMF to dissolve and remove any unreacted ligand. The final product was isolated by vacuum filtration. The isolated needle crystals were used for structure and physical characterizations.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-26-5, its application will become more common.

Reference:
Article; Wibowo, Arief C.; Smith, Mark D.; Yeon, Jeongho; Halasyamani, P. Shiv; Zur Loye, Hans-Conrad; Journal of Solid State Chemistry; vol. 195; (2012); p. 94 – 100;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 100-26-5 ,Some common heterocyclic compound, 100-26-5, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION 1 dimethyl Pyridine-2,5-dicarboxylate To a stirred slurry of 2,5-pyridinedicarboxylic acid (2407 g; 14.4 mol) in methanol (8.0 liter) at -5 to -10C, thionylchloride (3430 g; 2.10 liters; 28.8 mol) was added dropwise while maintaining the temperature in the -5 to -10C range. After completing the addition, the reaction was allowed to warm to ambient temperature, and stirred for 18 hours. The resulting solution was concentrated in vacuo to a volume of 4 liters, and an equal volume of water was added. The PH of the well-stirred mixture was then adjusted to 10 with saturated aqueous sodium carbonate. Solids were removed by filtration. The organic layer of the filtrate was separated, washed with water (8 liters), and dried in vacuo to afford the title compound (2250 g; 80% yield) as an amorphous solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-26-5, 2,5-Pyridinedicarboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; EP536173; (1995); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100-26-5, name is 2,5-Pyridinedicarboxylic acid, the common compound, a new synthetic route is introduced below. SDS of cas: 100-26-5

To a suspension of pyridine-2,5-dicarboxylic acid (20 g, 120 mmol) in dichloromethane (396 mL) and DMF (6.6 mL) was added oxalyl chloride (60.96 g, 480 mmol) dropwise over 20 minutes. After 16 hours at ambient temperature, the reaction mixture was concentrated in vacuo and the residue azeotroped with toluene. The residue was taken up in cold (00C) methanol (276 mL) and stirred for 15 minutes. The resultant solution was concentrated in vacuo and the residue taken up in ethyl acetate. The mixture was washed with a saturated aqueous solution of sodium bicarbonate, water and brine. A portion of the product was collected as a white precipitate. The organic phase was isolated, dried (Na2SO4), filtered and concentrated in vacuo to afford the title compound as a white solid (combined material obtained : 22.93 g, 98%). LCMS (method B): Rx = 2.48 min, [M+H]+ = 196.

The synthetic route of 100-26-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; WO2009/85983; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100-26-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-26-5 as follows.

Step 1. Dimethyl pyridine-2.5-dicarboxylate SOCI2 (855 g, 7.2 mol) was added dropwise into the solution of pyridine-2,5-dicarboxylate (500 g, 3.0 mol) in MeOH (5 L) at room temperature. The mixture was stirred at 70 C overnight. After cooling, the mixture was evaporated, and the residue was added EA (5 L), followed by Na2C03 (sat.) until PH>7. The mixture was separated and the aqueous layer was extracted with EA (1 L*3). The combined organic layer was washed with brine, dried over Na2SC>4, filtered and concentrated to give dimethyl pyridine-2,5-dicarboxylate. The product was used for next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-26-5, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph, A.; ALHASSAN, Abdul-Basit; ANAND, Rajan; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; YU, Wensheng; YU, Younong; LIU, Shilan; WU, Hao; YANG, Chundao; (120 pag.)WO2016/109215; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

A solution of compound 23 (10 g, 59.9 mmol)Dissolved in methanol (lOOmL)In the ice bath slowly addedTo a solution of dichlorosulfoxide (28.5 mL, 239.5 mmol)The reaction was refluxed for 4 h, Followed by spin-drying to give compound 24 (11.4 g, 98.3percent).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Patent; Jiangnan University; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Wang Wenlong; Li Jia; Feng Bonian; Yang Donglin; Gao Lixin; Ye Huihua; Xu Haojie; Zhao Yanan; Zhang Siqi; (51 pag.)CN104418811; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem