Category: 100-26-5

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-26-5 as follows., 100-26-5

10311] Thionyl chloride (2.2 mE) was added dropwise to MeOH (14 mE) while stirring on ice. 2,5-Pyridinedicarbox- ylic acid (1.0 g, 6.0 mmoles) was added and the reaction heated at reflux for 3 hr. The reaction was cooled and the solvent removed under reduced pressure. The resulting residue was dissolved in DCM (15 mE), afier which saturated Na2CO3 (15 mE) was added while stirring on ice. Theaqueous layer was extracted with DCM (3x 15 mE), and the combined organics were washed with saturated Na2CO3 (2×40 mE), dried over Na2SO4(s), and concentrated under reduced pressure to afford the title compound (915 mg, 78%) as a pale yellow solid. ?H NMR (500 MHz, CDC13) oe 9.32 (dd, J=0.5, 2.0 Hz, 1H), 8.47 (dd, J=2.0, 8.0 Hz, 1H), 8.23 (dd, J=0.5, 8.0 Hz, 1H), 4.06 (s, 3H), 4.01 (s, 3H); ?3C NMR (125 MHz, CDC13) oe 165.0, 164.9, 150.8, 150.8, 138.4, 128.6, 124.7, 53.3, 52.8; HRMS (ESI) mlz 196.0600 [calc?d for C9H,QNO4 (M+H) 196.0605].

The chemical industry reduces the impact on the environment during synthesis 100-26-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; RAINES, Ronald T.; Vasta, James; (50 pag.)US2016/280701; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Three series of [Ln2(pydc)2(SO4) (H2O)x]yH2O (x= 0, 2, 3; y= 0, 2,6), differing in numbers of the coordinated (x) and the crystallizing (y) water molecules, were hydrothermally synthesized through subtlealteration in reaction temperature and time (Scheme 1). [Ln2(pydc)2(SO4) (H2O)2]6H2O; LnLa (Ia), Pr (Ib), Nd (Ic). To synthesize Ia, a solution of La2(SO4)38H2O (0.1420 g, 0.2000 mmol) and H2pydc (0.0334 g, 0.200 mmol) was prepared using 10.00 ml of deionized water, into which 50.0 muL triethylamine was added to adjust pH of the solution to 5. The solution was then transferred into a 23mL Teflon lined hydrothermal reactor, which was then sealed and heated at two different temperatures, i.e. 80 and 120 C, for 1 day. After the reaction was cooled down to room temperature, colorless block crystals of Ia was obtained in ca. 35% yield based on LaIII.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Sinchow; Chuasaard, Thammanoon; Yotnoi, Bunlawee; Rujiwatra, Apinpus; Journal of Solid State Chemistry; vol. 278; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5 ,Some common heterocyclic compound, 100-26-5, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Concentrated sulfuric acid (3.9 mL, 71.6 mmol) was added dropwise over 15 minutes to a stirred suspension of 2,5-pyridinedicarboxylic acid (3.0 g, 17.9 mol) in absolute ethanol (10 mL) and the resulting mixture heated to reflux for 18 hours. The solution was allowed to cool to room temperature and the solvents evaporated under reduced pressure. Saturated NaHCC>3 solution was added to the residue to adjust the pH to -8 then the aqueous phase was extracted with EtOAc (4 x 50 mL). The combined organic extracts were washed with brine (30 mL), dried (Na2S04) and evaporated under reduced pressure to leave the title compound (3.0 g, 75%) which was used without further purification.

According to the analysis of related databases, 100-26-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SENTINEL ONCOLOGY LIMITED; BOYLE, Robert George; WALKER, David Winter; BOYCE, Richard Justin; (165 pag.)WO2018/197714; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a round bottom flask connected with condenser, pyridine-2, 5- dicarboxylic acid (20 mmol, 3.34 g), SOCI2 (60 mmol, 7.14 g) and 5 ml_ of DMF were added and the reaction was carried out at 90C under argon for 4 h. The reaction mixture was then cooled down to room temperature, Et3N (6 equiv. , 1 6.8 ml_) and glycerol carbonate (80 mmol, 9.45 g in 1 2 mL of THF) were added slowly and was further heated at 90C overnight. After the reaction, the excess amount of Et3N, SOCI2 and solvent were removed under vacuum. The product bis((2-oxo-1 ,3-dioxolan-4-yl)methyl)pyridine-2,5- dicarboxylate was isolated as a white solid, filtered and washed with water (30 mL, 2 times) and with Et20 (30 mL, 2 times) to give 4.61 g (1 2.6 mmol) of pure product (63%) which was characterized by 1 H, 13C-NMR and HRMS. 1 H- NMR (CDCb, 400 MHz) : 9.1 9 (dd, J = 2.1 , 0.8 Hz, 1 H), 8.49 (dd, J = 8.2, 2.2 Hz, 1 H), 8.21 (dd, J = 8.1 , 0.8 Hz, 1 H), 5.36 – 5.05 (m, 2H), 4.84 – 4.31 (m, 8H). 13C NMR (CDCb, 100 MHz): d= 168.8, 168.6, 159.9, 159.8, 1 55.5, 1 55.4, 143.8, 1 33.2, 1 30.3, 79.4, 79.3, 71 .4, 71 .3, 70.2, 70.1 . HR-MS (ESI) (M+H)+ m/z Calcd. for CisHuNOio: 368.061 2. Found: 368.061 0.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; SEAYAD, Jayasree; JANA, Satyasankar; SEAYAD, Abdul Majeed; (115 pag.)WO2019/190409; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-26-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

fac-[NEt4]2[Re(CO)3(Br)3] (100.0 mg, 0.130 mmol) was dissolved in water at pH 2.2. Silver nitrate (66.0 mg, 0.389 mmol) was added to the solution and stirred for 24 h at room temperature. After the reaction mixture was filtered (AgBr), 2,5-pyridine dicarboxylic acid(22.0 mg, 0.133 mmol) was added to the solution and stirred under N2 at room temperature for 48 h. The mixture was filtered and the filtrate (pH 2.5) was dried in vacuo. Yield: 55.4 mg, 94 %. IR (KBr,cm-1): mCO = 1899, 2017, 2043. 1H NMR (CD3COCD3): delta = 7.93 (d,1H, J = 8.1 Hz), 8.58 (dd, 1H, J = 1.8 Hz, 8.1 Hz), 9.47 (s, 1H). 13CNMR (CD3COCD3): delta = 128.7, 132.9, 142.7, 151.6, 154.5, 164.5, 178.0, 195.0, 197.6, 198.1. HPLC: 17.84 min. Anal. Calc. C, 26.43;H, 1.33; N, 3.08. Found: C, 26.45; H, 1.30; N, 3.12%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Schutte-Smith; Visser; Polyhedron; vol. 89; (2015); p. 122 – 128;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem