Category: 100-48-1

Wang, Fang; Qin, Jian; Zhu, Shengqing; Chu, Lingling published their research in RSC Advances in 2021. The article was titled 《Organic-photoredox-catalyzed three-component sulfonylative pyridylation of styrenes》.Application of 100-48-1 The article contains the following contents:

An efficient, metal-free protocol for the three-component sulfonylative pyridylation of alkenes via organic-photoredox catalysis was described. Metal-free process enabled the direct and selective installation of sulfonyl and heteroaryl motifs and tolerated a wide array of functional groups as well as complex mol. scaffolds, which complemented previous methods and was of great interest in pharmaceutical research. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Heterogeneous Copper(I)-Catalyzed Cascade Addition-Oxidative Cyclization of Nitriles with 2-Aminopyridines or Amidines: Efficient and Practical Synthesis of 1,2,4-Triazoles》 were Xia, Jianhui; Huang, Xue; Cai, Mingzhong. And the article was published in Synthesis in 2019. Recommanded Product: 4-Cyanopyridine The author mentioned the following in the article:

The heterogeneous cascade addition-oxidative cyclization of nitriles with 2-aminopyridines or amidines was achieved in 1,2-dichlorobenzene or DMSO at 120-130 °C by using a 1,10-phenanthroline-functionalized MCM-41-supported copper(I) complex [Phen-MCM-41-CuBr] as the catalyst and air as the oxidant. The approach was used to generate a wide variety of 1,2,4-triazole derivatives, e.g., I and II, in mostly high yields. This heterogeneous copper(I) catalyst could be easily prepared in a two-step procedure from com. or readily available and inexpensive reagents and it exhibited higher catalytic activity than the CuBr/1,10-Phen system. Phen-MCM-41-CuBr was also easy to recover and was recyclable up to eight times with almost consistent activity. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Du, Yun; Sun, Chenglong; Shen, Yuru; Liu, Luyao; Chen, Mingjian; Xie, Qingji; Xiao, Hongbo published an article in 2022. The article was titled 《Anodic Stripping Voltammetric Analysis of Trace Arsenic(III) on a Au-Stained Au Nanoparticles/Pyridine/Carboxylated Multiwalled Carbon Nanotubes/Glassy Carbon Electrode》, and you may find the article in Nanomaterials.Safety of 4-Cyanopyridine The information in the text is summarized as follows:

A Au-stained Au nanoparticle (Aus)/pyridine (Py)/carboxylated multiwalled carbon nanotubes (C-MWCNTs)/glassy carbon electrode (GCE) was prepared for the sensitive anal. of As(III) by cast-coating of C-MWCNTs on a GCE, electroreduction of 4-cyanopyridine (cPy) to Py, adsorption of gold nanoparticles (AuNPs), and gold staining. The Py/C-MWCNTs/GCE can provide abundant active surface sites for the stable loading of AuNPs and then the AuNPs-initiated Au staining in HAuCl4 + NH2OH solution, giving a large surface area of Au on the Aus/Py/C-MWCNTs/GCE for the linear sweep anodic stripping voltammetry (LSASV) anal. of As(III). At a high potential-sweep rate of 5 V s-1, sharp two-step oxidation peaks of As(0) to As(III) and As(III) to As(V) were obtained to realize the sensitive dual-signal detection of As(III). Under optimal conditions, the ASLSV peak currents for oxidation of As(0) to As(III) and of As(III) to As(V) are linear with a concentration of As(III) from 0.01 to 8μM with a sensitivity of 0.741 mA μM-1 and a limit of detection (LOD) of 3.3 nM (0.25 ppb) (S/N = 3), and from 0.01 to 8.0μM with a sensitivity of 0.175 mA μM-1 and an LOD of 16.7 nM (1.20 ppb) (S/N = 3), resp. Determination of As(III) in real water samples yielded satisfactory results. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Tetrahedron included an article by Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji. Computed Properties of C6H4N2. The article was titled 《NNN pincer Ru(II)-catalyzed dehydrogenative coupling of 2-aminoarylmethanols with nitriles for the construction of quinazolines》. The information in the text is summarized as follows:

An efficient NNN pincer Ru(II)-catalyzed preparation of quinazolines via acceptorless dehydrogenative strategy was developed. Under the optimized conditions, a broad range of substituted o-aminobenzyl alcs. and (hetero)aryl or alkyl nitriles were well tolerated to afford various 2-substituted quinazolines in high yields. Subsequently, a set of control experiments was performed to elucidate the reaction mechanism, which underwent alc. oxidation, nitrile hydration and cyclocondensation steps. This protocol was featured with several advantages, such as environmental benignity, operational simplicity, broad substrate scope (compatible with aliphatic nitriles, up to 87% yield) and short reaction time (mostly in 2 h). The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Intramolecular electrochemical dehydrogenative N-N bond formation for the synthesis of 1,2,4-triazolo[1,5-a]pyridines》 was written by Li, Yong; Ye, Zenghui; Chen, Na; Chen, Zhenkun; Zhang, Fengzhi. Formula: C6H4N2This research focused ontriazolopyridine preparation green chem; amidine pyridyl electrochem dehydrogenation. The article conveys some information:

A metal- and oxidant-free intramol. dehydrogenative N-N bond formation has been developed under mild and scalable electrolytic conditions. Various valuable 1,2,4-triazolo[1,5-a]pyridines I (R1 = t-Bu, cyclopropyl, 2,6-dichlorophenyl, 2-naphthyl, pyridin-4-yl, etc.; R2 = H, Me; R3 = H, Me, Et, F, Cl, 4-methylphenyl, 2-thiophenyl; R4 = H, Me, MeO; R5 = H, Me, Cl; R3R4 = CH=CH-CH=CH) were synthesized efficiently from the readily available N-(2-pyridyl)amidines II. The reactions were conducted in a simple undivided cell under constant current conditions with n-Bu4NBr as both the redox mediator and the electrolyte. This protocol was applied to the efficient synthesis of key intermediates for anti-diabetic compounds After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4-CyanopyridineIn 2019 ,《Synthesis of Secondary Aldimines from the Hydrogenative Cross-Coupling of Nitriles and Amines over Al2O3-Supported Ni Catalysts》 was published in ACS Catalysis. The article was written by Zhou, Peng; Jiang, Liang; Wang, Shuguo; Hu, Xun; Wang, Hongming; Yuan, Ziliang; Zhang, Zehui. The article contains the following contents:

A heterogeneous Ni catalyst was discovered to be active in the synthesis of secondary cross-imines via hydrogenative coupling of nitriles and amines. The mesoporous Al2O3-supported Ni nanoparticles (abbreviated as Ni/m-Al2O3-600, where 600 represents the reduction temperature) were active in hydrogenative coupling of nitriles and amines reaction at 80 °C and 1 bar H2, affording corresponding cross-imines with yields in the range 64.1-98.1%. D. functional theory calculations reveal the hydrogenation of benzonitrile (PhCN) to benzylamine (PhCH2NH2) has higher activation energy than that for hydrogenative cross-coupling of PhCN and RNH2 on the Ni/m-Al2O3-600 catalyst, suggesting the latter reaction is more favorable. The theor. calculations are in good agreement with our exptl. results. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Name: 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Jiale; Yuan, Tao; Zheng, Meifang; Wang, Xinchen published their research in ACS Catalysis in 2021. The article was titled 《Metal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids》.COA of Formula: C6H4N2 The article contains the following contents:

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids RC(O)OH (R = 3,5-dimethylphenyl, 2-(4-methylphenyl)ethyl, diphenylmethyl, isoquinolin-1-yl, etc.) was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidizes carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed through the decarboxylation smoothly; and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycling tests and a gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chem. toolbox. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mavrova, Anelia; Dimov, Stephan; Sulikovska, Inna; Yancheva, Denitsa; Iliev, Ivan; Tsoneva, Iana; Staneva, Galya; Nikolova, Biliana published an article in 2022. The article was titled 《Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines》, and you may find the article in Molecules.SDS of cas: 100-48-1 The information in the text is summarized as follows:

Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were tested in vitro against human and mouse cell lines. The examination of the compound effects on BLAB 3T3 and MFC-10A cells showed that they are safe, making them suitable for subsequent experiments to establish their antitumor activity. The photoirritancy factor of the compounds was calculated Using the MTT test, the antiproliferative activity to MCF-10A, MCF-7 and MDA-MB-231 cell lines was estimated The best antiproliferative effect in respect to the MCF-7 cell line revealed compound 2 with IC50 4.3 ± 0.11 μg/mL (0.013 μM). The highest selective index with respect to MCF-7 cells was shown by compound 3 (SI = 19.3), and to MDA-MB-231 cells by compound 2 (SI = 3.7). Based on energy anal., the most stable conformers were selected and optimized by means of d. functional theory (DFT). Ligand efficiency, ligand lipophilicity efficiency and the physicochem. parameters of the target 4-amino-thienopyrimidines were determined The data obtained indicated that the lead compound among the tested substances is compound 2. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Metal-Free Radical-Mediated C(sp3)-H Heteroarylation of Alkanes》 was published in Organic Letters in 2020. These research results belong to Shao, Xin; Wu, Xinxin; Wu, Shuo; Zhu, Chen. COA of Formula: C6H4N2 The article mentions the following:

Herein we disclose a metal-free, N/O-centered radical-promoted Minisci reaction, in which the coupling of various heteroarenes with simple alkanes proceeds under mild conditions. The reaction conditions are neutral; no extra acid is added to preactivate N-heteroarenes in the Minisci reaction. The N-/O-centered radicals are generated directly from amide (TsNHMe) or alc. (CF3CH2OH) under visible-light irradiation This green and eco-friendly synthetic process may find potential use in medicinal chem. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Science included an article by Cao, Jia; Wang, Guoqiang; Gao, Liuzhou; Chen, Hui; Liu, Xueting; Cheng, Xu; Li, Shuhua. Application In Synthesis of 4-Cyanopyridine. The article was titled 《Perfluoroalkylative pyridylation of alkenes via 4-cyanopyridine-boryl radicals》. The information in the text is summarized as follows:

A metal-free and photo-free method for the perfluoroalkylative pyridylation of alkenes R1R2C=CH2 [R1 = 4-MeC6H4, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; R2 = H, Me, Et, Pr; R1R2 = -(CH2)5-] has been developed via a combination of computational and exptl. studies. D. functional theory calculations and control experiments indicate that the homolysis of R3X [R3 = CF3, CF2CF2Cl, CF(CF3)2, etc.; X = Br, I] bonds by the 4-cyanopyridine-boryl radicals in situ generated from 4-cyanopyridine and B2pin2 is the key step. Sequential addition of R3 radicals to alkenes and the selective cross-coupling of the resulting alkyl radicals and 4-cyanopyridine-boryl radicals gives alkene difunctionalization products I with a quaternary carbon center. This method exhibits a broad substrate scope and good functional group compatibility. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem