Category: 100-48-1

《Expanding the repertoire of nitrilases with broad substrate specificity and high substrate tolerance for biocatalytic applications》 was written by Sunder, Avinash Vellore; Shah, Shikha; Rayavarapu, Pratima; Wangikar, Pramod P.. Computed Properties of C6H4N2 And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2020. The article conveys some information:

Enzymic conversion of nitriles to carboxylic acids by nitrilases has gained significance in the green synthesis of several pharmaceutical precursors and fine chems. Although nitrilases from several sources have been characterized, there exists a scope for identifying broad spectrum nitrilases exhibiting higher substrate tolerance and better thermostability to develop industrially relevant biocatalytic processes. Through genome mining, we have identified nine novel nitrilase sequences from bacteria and evaluated their activity on a broad spectrum of 23 industrially relevant nitrile substrates. Nitrilases from Zobellia galactanivorans, Achromobacter insolitus and Cupriavidus necator were highly active on varying classes of nitriles and applied as whole cell biocatalysts in lab scale processes. Z. galactanivorans nitrilase could convert 4-cyanopyridine to achieve yields of 1.79 M isonicotinic acid within 3 h via fed-batch substrate addition The nitrilase from A. insolitus could hydrolyze 630 mM iminodiacetonitrile at a fast rate, effecting 86% conversion to iminodiacetic acid within 1 h. The arylaliph. nitrilase from C. necator catalyzed enantioselective hydrolysis of 740 mM mandelonitrile to (R)-mandelic acid in 4 h. Significantly high product yields suggest that these enzymes would be promising additions to the suite of nitrilases for upscale biocatalytic application. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4-CyanopyridineIn 2019 ,《Three AgI, CuI and CdII coordination polymers based on the new asymmetrical ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole: syntheses, characterization and emission properties》 was published in Acta Crystallographica, Section C: Structural Chemistry. The article was written by Jin, Guo-Xia; You, Tian-Chao; Ma, Jian-Ping. The article contains the following contents:

The new asym. organic ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole (L, C17H13N5O), containing pyridine and imidazole terminal groups, as well as potential oxdiazole coordination sites, was designed and synthesized. The coordination chem. of L with soft AgI, CuI and CdII metal ions was investigated and three new coordination polymers (CPs), namely, catena-poly[[silver(I)-μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole] hexafluoridophosphate], {[Ag(L)]PF6}n, catena-poly[[copper(I)-di-μ-iodido-copper(I)-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)] 1,4-dioxane monosolvate], {[Cu2I2(L)2]·C4H8O2}n, and catena-poly[[[dinitratocopper(II)]-bis(μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)]-methanol-water (1/1/0.65)], {[Cd(L)2(NO3)2]·2CH4O·0.65H2O}n, were obtained. The exptl. results show that ligand L coordinates easily with linear AgI, tetrahedral CuI and octahedral CdII metal atoms to form one-dimensional polymeric structures. The intermediate oxadiazole ring does not participate in the coordination interactions with the metal ions. In all three CPs, weak π-π interactions between the nearly coplanar pyridine, oxadiazole and benzene rings play an important role in the packing of the polymeric chains. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shoair, Abdel Ghany F.; Shanab, Mai M. A. H.; Mahmoud, Mohamed H. H. published an article in 2021. The article was titled 《Electrochemical and catalytic properties of oxo-ruthenate(VI) in aqueous alkaline medium》, and you may find the article in International Journal of Electrochemical Science.HPLC of Formula: 100-48-1 The information in the text is summarized as follows:

The complex K2[Ru(III)Cl5(H2O)] has been prepared and characterized by different spectroscopic techniques (IR and UV-VIS). The electrochem. properties of this complex were investigated at different pH′s using Robinson buffer solutions The cyclic voltammograms exhibited three redox different oxidation and potential peaks due to generation of Ru(III), Ru(IV), Ru(V) and Ru(VI) ions. The catalytic activity of K2[Ru(III)Cl5(H2O)] towards the hydration of some aromatic and three heterocyclic nitriles to their corresponding amides was investigated with excess of three co-oxidants K2S2O8, NaOCl and KBrO3. A number of factors have been investigated and the best yields were obtained with K2S2O8 as a co-oxidant in a 1.0 M KOH at 80 °C. Both spectroscopic and electrochem. techniques were used to establish the nature of active species in this catalytic reaction and the active catalyst was found to be K2[Ru(VI)O3(OH)2], as well as to explain the possible reaction mechanism. The suggested mechanism included the coordination of nitrile to ruthenium center followed by liberation of the corresponding amide and the active complex again. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Richardson, Keith; Brown, Jeffery published an article in 2021. The article was titled 《in silico reagent design for electron-transfer dissociation on a Q-TOF》, and you may find the article in Journal of the American Society for Mass Spectrometry.HPLC of Formula: 100-48-1 The information in the text is summarized as follows:

Electron-transfer dissociation is an important technique capable of probing the primary and higher order structure of a wide variety of biomols. and yielding information that is often inaccessible using other common MS methods. The source of the electron used to initiate the fragmentation event is a radical anion, and the fragmentation process therefore depends intimately on the electronic properties of both the reagent and analyte ions. A good reagent must ionize easily and be sufficiently robust to survive transport to the reaction location, but must also be capable of donating an electron to analyte cations efficiently enough to overcome competition with other ion-ion reaction channels. Inspired by the work of Gunawardena et al. (), an in silico workflow to allow prescreening of potential electron-transfer reagents for use in glow-discharge sources is described. Approx. 150 candidate mols. have been characterized using this workflow. We discuss in detail the properties of a selected subset of singly and doubly substituted benzenes and introduce five effective new reagents that have been identified as a result of this work.4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Constructing antibacterial polymer nanocapsules based on pyridine quaternary ammonium salt》 was written by Zeng, Minghao; Xu, Jiayun; Luo, Quan; Hou, Chunxi; Qiao, Shanpeng; Fu, Shuang; Fan, Xiaotong; Liu, Junqiu. COA of Formula: C6H4N2This research focused ontrispyridyl triazine dibromoethane copolymer nanocapsule preparation antibacterial; Antibacterial; Cationic polymer nanocapsule; Pyridine quaternary ammonium salt. The article conveys some information:

Excessive use of antibiotics accelerates the development and spread of drug-resistant strains, which is a huge challenge for the field of medical health worldwide. Quaternary ammonium salt polymers are considered to be membrane-active bactericidal groups with vast potential to control bacterial infections and inhibit drug resistance. Herein, we report on the creative synthesis and characterization of novel antimicrobial polymer nanocapsules based on pyridine quaternary ammonium salt. The antimicrobial polymer nanocapsules were formed by reaction of C3 sym. rigid monomer 2,4,6-tris(4-pyridyl)-1,3,5-triazine (TPT) and a flexible linker 1,2-dibromoethane. The polymer nanocapsule was constructed as a cationic hollow sphere composed of a two-dimensional sheet whose main chain was formed by the pyridine quaternary ammonium salt, and a part of the bromide ion was adsorbed on the sphere. This hollow nanocapsule was characterized in detail by DLS, SEM, TEM, AFM, EDS and EA. When the cationic polymer nanocapsules are close to the Gram-neg. Escherichia coli, the neg. charged phospholipid mols. in the bacterial membrane are attracted to the cationic surface and lead to rupture of cells. SEM confirmed the breakage of Escherichia coli membranes. The min. inhibitory concentration was found to be 0.04 mg/mL, and the min. bactericidal concentration was 0.1 mg/mL. Our experiments demonstrated that the adsorption of neg. charged phospholipid mols. on the surface of the pyridine quaternary ammonium salt polymer can kill Gram-neg. bacteria without inserting quaternary ammonium salt hydrophobic groups into the cell membrane. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Crystal structures of a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands》 was written by Rood, Jeffrey A.; Reehl, Steven R.; Jacoby, Kaitlyn A.; Oliver, Allen. Safety of 4-CyanopyridineThis research focused onvanadium complex crystal structure crystallization; bidentate ligands; cis/trans isomers; coordination compound; crystal structure; vanadium(IV). The article conveys some information:

Crystal structures for a series of bis(acetylacetonato)oxovanadium(IV) complexes containing N-donor pyridyl ligands are reported, namely, bis(acetylacetonato-κ2O,O′)oxido(pyridine-κN)vanadium(IV), [V(C5H7O2)2O(C5H5N)], 1, bis(acetylacetonato-κ2O,O′)oxido(pyridine-4-carbonitrile-κN)vanadium(IV), [V(C5H7O2)2O(C6H4N2)], 2, and bis(acetylacetonato-κ2O,O′)(4-methoxypyridine-κN)oxidovanadium(IV), [V(C5H7O2)2O(C6H7NO)], 3, Compounds 1-3 have the formulas VO(C5H7O2)2L, where L = pyridine (1), 4-cyano-pyridine (2), and 4-methoxypyridine (3). Compound 1 was previously reported [Meicheng et al. (1984). Kexue Tongbao, 29, 759-764 and DaSilva, Spiazzi, Bortolotto & Burrow (2007). Acta Crystallogr., E63, m2422] and redetermined here at cryogenic temperatures Compounds 1 and 2 as pyridine and 4-cyanopyridine adducts, resp., crystallize as distorted octahedral structures with the oxo and pyridyl ligands trans to one another. A crystallog. twofold axis runs through the O-V-N bonds. Compound 3 containing a 4-methoxypyridine ligand crystallizes as a distorted octahedral structure with the oxo and pyridyl ligands cis to one other, removing the twofold symmetry seen in the other complexes. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diketopyrrolopyrrole-based multifunctional ratiometric fluorescent probe and γ-glutamyltranspeptidase-triggered activatable photosensitizer for tumor therapy》 was published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2020. These research results belong to Yang, Zhicheng; Xu, Weibo; Wang, Jian; Liu, Lingyan; Chu, Yanmeng; Wang, Yu; Hu, Yue; Yi, Tao; Hua, Jianli. Electric Literature of C6H4N2 The article mentions the following:

Photosensitizers can generate highly reactive oxygen species (ROS) by light excitation, causing cell damage and apoptosis. However, conventional photosensitizers cannot kill cancer cells selectively. In this work, we report a series of diketopyrrolopyrrole (DPP)-based photosensitizers, in which DPP-py with one pyridine group exhibits superior photodynamic killing effect on tumor cells. Furthermore, by introducing 4-bromomethyl-Ph glutamic acid in DPP-py, we adopt a strategy involving the intramol. charge transfer effect to develop a multifunctional DPP-based ratiometric fluorescent probe and activatable photosensitizer DPP-GGT, which can target the tumor-related biomarker γ-glutamyltranspeptidase (γ-GT). DPP-GGT shows highly selective and obvious fluorescent changes from red to yellow for γ-GT. More importantly, DPP-GGT exhibits specific photodynamic killing effects on human hepatic cancer cells HepG2 due to the high activity of endogenous γ-GT but no marked phototoxicity toward low-γ-GT-expressing breast cancer cells MCF-7 or normal hepatocyte cells L02. The results demonstrate that DPP-GGT has great potential for the tumor-specific activatable photodynamic anticancer therapy. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem