Category: 100-48-1

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 100-48-1, Name is Isonicotinonitrile, molecular formula is C6H4N2, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Abdel-aziz, Hassan M., once mentioned the new application about 100-48-1, Recommanded Product: 100-48-1.

Facile synthesis and antiproliferative activity of new 3-cyanopyridines

Background Pyridines have been reported to possess various pharmacological activities. Results Sodium 3-oxo-3-(2-oxo-2H-chromen-3-yl)prop-1-en-1-olate (2) and sodium 3-oxo-3-(3-oxo-3H-benzo[f]chromen-2-yl)prop-1-en-1-olate (7) were prepared and reacted with 2-cyano-N’-(1-aryl(heteryl)ethylidene)acetohydrazides 3a-d to produce 2-oxo-1,2-dihydropyridine-3-carbonitrile derivatives 5a-d and 9a-d, respectively, in good yields. Also, 3a-d reacted with sodium (2-oxocyclopentylidene)methanolate (11a) or sodium (2-oxocyclohexylidene) methanolate (11b) to yield 2-oxo-tetrahydro-1H-cyclopenta[b]pyridine-3-carbonitriles 13a-d and 2-oxo-hexahydroquinoline-3-carbonitriles 13e-h, respectively. The mechanisms that account for the formation of the products are discussed. Additionally, the structures of all the newly synthesized products are confirmed, based on elemental analysis and spectral data. Several of the newly synthesized compounds are evaluated for their antitumor activity against HEPG2 and their structure activity relationship (SAR) was studied. Conclusions The results revealed that the pyridine derivatives 5c and 5d (IC50 = 1.46, 7.08 mu M, respectively) have promising antitumor activity against liver carcinoma cell line (HEPG2), compared to the reference drug, doxorubicin.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 100-48-1. The above is the message from the blog manager. Recommanded Product: 100-48-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 100-48-1, 100-48-1, Name is Isonicotinonitrile, molecular formula is C6H4N2, belongs to pyridine-derivatives compound. In a document, author is Sirakanyan, S. N., introduce the new discover.

Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines

Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 100-48-1. Product Details of 100-48-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: pyridine-derivatives, 100-48-1, Name is Isonicotinonitrile, SMILES is N#CC1=CC=NC=C1, belongs to pyridine-derivatives compound. In a document, author is Polunin, Ruslan A., introduce the new discover.

Versatile Reactivity of Mn-II Complexes in Reactions with N-Donor Heterocycles: Metamorphosis of Labile Homometallic Pivalates vs. Assembling of Endurable Heterometallic Acetates

Reaction of 2,2 ‘-bipyridine (2,2 ‘-bipy) or 1,10-phenantroline (phen) with [Mn(Piv)(2)(EtOH)](n) led to the formation of binuclear complexes [Mn-2(Piv)(4)L-2] (L = 2,2 ‘-bipy (1), phen (2); Piv(-) is the anion of pivalic acid). Oxidation of 1 or 2 by air oxygen resulted in the formation of tetranuclear Mn-II/III complexes [Mn4O2(Piv)(6)L-2] (L = 2,2 ‘-bipy (3), phen (4)). The hexanuclear complex [Mn-6(OH)(2)(Piv)(10)(pym)(4)] (5) was formed in the reaction of [Mn(Piv)(2)(EtOH)](n) with pyrimidine (pym), while oxidation of 5 produced the coordination polymer [Mn6O2(Piv)(10)(pym)(2)](n) (6). Use of pyrazine (pz) instead of pyrimidine led to the 2D-coordination polymer [Mn-4(OH)(Piv)(7)(mu(2)-pz)(2)](n) (7). Interaction of [Mn(Piv)(2)(EtOH)](n) with FeCl3 resulted in the formation of the hexanuclear complex [(Mn4Fe2O2)-Fe-II-O-III(Piv)(10)(MeCN)(2)(HPiv)(2)] (8). The reactions of [MnFe2O(OAc)(6)(H2O)(3)] with 4,4 ‘-bipyridine (4,4 ‘-bipy) or trans-1,2-(4-pyridyl)ethylene (bpe) led to the formation of 1D-polymers [MnFe2O(OAc)(6)L-2](n)center dot 2nDMF, where L = 4,4 ‘-bipy (9Greek ano teleia2DMF), bpe (10Greek ano teleia2DMF) and [MnFe2O(OAc)(6)(bpe)(DMF)](n)center dot 3.5nDMF (11 center dot 3.5DMF). All complexes were characterized by single-crystal X-ray diffraction. Desolvation of 11 center dot 3.5DMF led to a collapse of the porous crystal lattice that was confirmed by PXRD and N-2 sorption measurements, while alcohol adsorption led to porous structure restoration. Weak antiferromagnetic exchange was found in the case of binuclear Mn-II complexes (J(Mn-Mn) = -1.03 cm(-1) for 1 and 2). According to magnetic data analysis (J(Mn-Mn) = -(2.69 divided by 0.42) cm(-1)) and DFT calculations (J(Mn-Mn) = -(6.9 divided by 0.9) cm(-1)) weak antiferromagnetic coupling between Mn-II ions also occurred in the tetranuclear {Mn-4(OH)(Piv)(7)} unit of the 2D polymer 7. In contrast, strong antiferromagnetic coupling was found in oxo-bridged trinuclear fragment {MnFe2O(OAc)(6)} in 11 center dot 3.5DMF (J(Fe-Fe) = -57.8 cm(-1), J(Fe-Mn) = -20.12 cm(-1)).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 100-48-1. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 100-48-1, Isonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H4N2, blongs to pyridine-derivatives compound. Computed Properties of C6H4N2

General procedure: To a stirred suspension of corresponding nitrile and hydroxylamine hydrochloride (1.5 equiv.) in EtOH (10 mL per gram of nitrile) a NaHCO3 (1.5 equiv.) was added. The reaction mixture was stirred under reflux for a 6 h. After the reaction had completed, the reaction mixture was concentrated under reduced pressure, and the residue was diluted with cold water (200 mL). The resulting precipitate was filtered off and washed with cold water (50 mL). N’-Hydroxyisonicotinimidamide (AM-1). Compound was synthesized by following GP1 starting from isonicotinonitrile (10 g, 0.1 mol) in 85% (11.6 g) yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-48-1, Isonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Article; Geyl, Kirill; Baykov, Sergey; Tarasenko, Marina; Zelenkov, Lev E.; Matveevskaya, Vladislava; Boyarskiy, Vadim P.; Tetrahedron Letters; vol. 60; 40; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-48-1, name is Isonicotinonitrile. A new synthetic method of this compound is introduced below., Recommanded Product: 100-48-1

General procedure: To a stirred mixture of nitrile (1.0 mmol) and thiosemicarbazide(1.1 mmol) was added trifluoroacetic acid (4 mL) and then themixture was refluxed for 6 h under stirring. After completion ofreaction cooled to room temperature and diluted with aqueousammonia. The precipitated solid was filtered off, washed with hotwater and dried in air. The product 14a-f were used in the next stepwithout further purification. Spectral data of compounds such as 5-phenyl-1,3,4-thiadiazol-2-amine (14a) [63], 5-(p-tolyl)-1,3,4-thiadiazol-2-amine (14b) [63], 5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-amine (14c) [64], 5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine (14d) [63], 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine(14e) [63] and 5-(thiophen-2-yl)-1,3,4-thiadiazol-2-amine (14f)[63] were agreement with literature report.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-48-1, Isonicotinonitrile.

Reference:
Article; Sakthivel, Palaniappan; Ilangovan, Andivelu; Kaushik, Mahabir Prasad; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 302 – 318;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-48-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-48-1, name is Isonicotinonitrile. A new synthetic method of this compound is introduced below.

Reference Example 2: Synthesis of 4-(5-amino-1,2,4-oxadiazol-3-yl)pyridine. 17.1 g of 4-cyanopyridine, 70 ml of water, 11.4 g of hydroxylamine hydrochloride and 8.7 g of Na2CO3 were stirred in an autoclave for 8 hours with heating at 70C and, after cooling, the resulting reaction mixture was mixed with 60 ml of water, heated again and then spontaneously cooled to obtain 20.8 g of isonicotinamidoxime.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-48-1, Isonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; KATAYAMA SEIYAKUSYO CO. Ltd.; Ajinomoto Co., Inc.; EP641797; (1995); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-48-1 , The common heterocyclic compound, 100-48-1, name is Isonicotinonitrile, molecular formula is C6H4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

NaOMe (5.4 g, 100 mmol) was added to a stirred solution of 4-pyridinecarbonitrile (10.0 g, 96.1 mmol) in dry MeOH (50 mL) and the mixture stirred at reflux temperature for 2 h. NH4Cl (11.0 g, 211 mmol) was added and the mixture stirred at reflux temperature for 2 h. The solvent was evaporated and the residue crystallised from water to give amidine*HCl 58 (7.54 g, 65percent) as a white powder: mp (H2O) 235-238 ¡ãC (lit.2 mp [H2O] 236-242 ¡ãC); 1H NMR d 9.51 (br s, 4 H, NH, NH2*HCl), 8.87 (dd, J = 4.4, 1.7 Hz, 2 H, H-2, H-6), 7.78 (dd, J = 4.4, 1.7 Hz, 2 H, H-3, H-5).

The synthetic route of 100-48-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bonnet, Muriel; Flanagan, Jack U.; Chan, Denise A.; Lai, Edwin W.; Nguyen, Phuong; Giaccia, Amato J.; Hay, Michael P.; Bioorganic and Medicinal Chemistry; vol. 19; 11; (2011); p. 3347 – 3356;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

100-48-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-48-1, name is Isonicotinonitrile, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.

70 g (1 mol) of hydroxyammonium chloride in 500 ml of methanol are introduced into the vessel, and a solution of 54 g (1 mol) of sodium methylate in 500 ml of methanol is added. After about 30 minutes, the sodium chloride is filtered off, 41.6 g (0.4 mol) of pyridine-4-carboxylic acid nitrile are added to the filtrate, and the batch is refluxed for 24 hours. Subsequently, the methanol is distilled off, and the residue is recrystallized from 2000 ml of isopropanol with simultaneously clarification with bleaching earth. 49.1 g (89.5% of th., relative to the nitrile used) of pyridine-4-amidoxime having a melting point of 207-208 C. are obtained which are reacted without further purification.

Statistics shows that 100-48-1 is playing an increasingly important role. we look forward to future research findings about Isonicotinonitrile.

Reference:
Patent; Hoechst Aktiengesellschaft; US4310665; (1982); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem