Category: 100-48-1

Electric Literature of C6H4N2In 2019 ,《Lewis Acid-Catalyzed Selective Reductive Decarboxylative Pyridylation of N-Hydroxyphthalimide Esters: Synthesis of Congested Pyridine-Substituted Quaternary Carbons》 appeared in ACS Catalysis. The author of the article were Gao, Liuzhou; Wang, Guoqiang; Cao, Jia; Chen, Hui; Gu, Yuming; Liu, Xueting; Cheng, Xu; Ma, Jing; Li, Shuhua. The article conveys some information:

A practical and efficient Lewis acid-catalyzed radical-radical coupling reaction of N-hydroxyphthalimide esters and 4-cyanopyridines with inexpensive bis(pinacolato)diboron as reductant has been developed. With ZnCl2 as the catalyst, a wide range of quaternary 4-substituted pyridines, including highly congested diarylmethyl and triarylmethyl substituents, could be selectively obtained in moderate to good yields with broad functional group tolerance. Combined theor. calculations and exptl. studies indicate that the Lewis acid could coordinate with the cyano group of the pyridine-boryl radical to lower the activation barrier of the C-C coupling pathway, leading to the formation of 4-substituted pyridines. Moreover, it could also facilitate the decyanation/aromatization of the radical-radical coupling intermediate. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2019 ,《Nitrogen-Doped Carbon-Supported Nickel Nanoparticles: A Robust Catalyst to Bridge the Hydrogenation of Nitriles and the Reductive Amination of Carbonyl Compounds for the Synthesis of Primary Amines》 appeared in ChemSusChem. The author of the article were Zhang, Yangmin; Yang, Hanmin; Chi, Quan; Zhang, Zehui. The article conveys some information:

An efficient method was developed for the synthesis of primary amines either from the hydrogenation of nitriles or reductive amination of carbonyl compounds The reactions were catalyzed by nitrogen-doped mesoporous carbon (MC)-supported nickel nanoparticles (abbreviated as MC/Ni). The MC/Ni catalyst demonstrated high catalytic activity for the hydrogenation of nitriles into primary amines in high yields (81.9-99 %) under mild reaction conditions (80° and 2.5 bar H2). The MC/Ni catalyst also promoted the reductive amination of carbonyl compounds for the synthesis of primary amines at 80° and 1 bar H2. The hydrogenation of nitriles and the reductive amination proceeded through the same intermediates for the generation of the primary amines. To the best of knowledge, no other heterogeneous non-noble metal catalysts have been reported for the synthesis of primary amines under mild conditions, both from the hydrogenation of nitriles and reductive amination. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic Dehydrosulfurization of Thioamides to Nitriles by Gold Nanoparticles Supported on Carbon Nanotubes》 were Gopi, Elumalai; Geertsen, Valerie; Gravel, Edmond; Doris, Eric. And the article was published in ChemCatChem in 2019. Application of 100-48-1 The author mentioned the following in the article:

A gold-carbon nanotube nanohybrid was shown to act as an efficient heterogeneous catalyst in the smooth and selective conversion of thioamides to the corresponding nitriles. The reaction was performed under mild conditions (room temperature, atm. pressure of oxygen) using only a gold loading of 0.35 mol %. Substituted aromatic or aliphatic nitriles were produced in very good to excellent yields and the catalyst could be easily recycled and reused over several consecutive cycles with no loss in dehydrosulfurization performances. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xiao; Yang, Chao; Gao, Han; Wang, Lei; Guo, Lin; Xia, Wujiong published their research in Organic Letters in 2021. The article was titled 《Reductive Arylation of Aliphatic and Aromatic Aldehydes with Cyanoarenes by Electrolysis for the Synthesis of Alcohols》.Application In Synthesis of 4-Cyanopyridine The article contains the following contents:

An electroreductive arylation reaction of aliphatic and aromatic aldehydes as well as ketones with electro-deficient (hetero)arenes is described. A variety of cyano(hetero)arenes and carbonyl compounds, especially aliphatic aldehydes, have been examined, providing secondary and tertiary alcs. in moderate to good yields. Mechanistic studies, including cyclic voltammetry (CV), ESR (EPR), and divided-cell experiments, support the generation of aliphatic ketyl radicals and persistent heteroaryl radical anions via cathodic reduction followed by radical-radical cross-coupling. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluorination as a route towards unlocking the hydrogen bond donor ability of phenolic compounds in self-assembled monolayers》 was published in CrystEngComm in 2020. These research results belong to Pinfold, Harry; Pattison, Graham; Costantini, Giovanni. HPLC of Formula: 100-48-1 The article mentions the following:

We report on the comparative performance of a simple diphenol and its fluorinated analog as hydrogen-bond-donating building blocks for the formation of multicomponent self-assembled monolayers. The fluorinated mol. is found to be a significantly more effective building block than its unfluorinated counterpart. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deeba, Rana; Chardon-Noblat, Sylvie; Costentin, Cyrille published an article in 2021. The article was titled 《Molecular Catalysis of Electrochemical Reactions: Competition between Reduction of the Substrate and Deactivation of the Catalyst by a Cosubstrate Application to N2O Reduction》, and you may find the article in ChemElectroChem.Computed Properties of C6H4N2 The information in the text is summarized as follows:

In the context of mol. catalysis of electrochem. reactions, the competition between reduction of the substrate and deactivation of the catalyst by a cosubstrate is investigated. It is a frequent situation because proton donors are ubiquitous cosubstrates in reductive electrochem. reactions and mol. catalysts, either transition metal complexes or organic aromatic mols., and are often prone to electrohydrogenation. We provide a formal kinetic anal. in the framework of cyclic voltammetry, and we show that the response is governed by two parameters and that the competition does not depend on the scan rate. From this anal. a methodol. is proposed to analyze such systems and then illustrated via the study of N2O to N2 electroreduction catalyzed by 4-cyanopyridine in acetonitrile electrolyte with water as proton donor. Incidentally, new insights into the mechanism of 4-cyanopyridine radical anion protonation are revealed. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2》 was written by Zhang, Sheng; Li, Lijun; Li, Xinru; Zhang, Junqi; Xu, Kun; Li, Guigen; Findlater, Michael. Electric Literature of C6H4N2 And the article was included in Organic Letters in 2020. The article conveys some information:

An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac)2 (acac = acetylacetone). This novel protocol was compatible with a broad range of electron-poor alkenes, which were commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac)2 differentiating reduction process of reaction partners. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst》 were Guo, Beibei; de Vries, Johannes G.; Otten, Edwin. And the article was published in Chemical Science in 2019. Quality Control of 4-Cyanopyridine The author mentioned the following in the article:

The catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyzed the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occurred under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration was proposed that is initiated by metal-ligand cooperative binding of the nitrile. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,CrystEngComm included an article by Torubaev, Y. V.; Skabitsky, I. V.. Application In Synthesis of 4-Cyanopyridine. The article was titled 《The energy frameworks of Aufbau synthon modules in 4-cyanopyridine co-crystals》. The information in the text is summarized as follows:

The supramol. arrangement of 4-cyanopyridine (4CNpy) in its native crystal form and its co-crystals with halogen bond (XB) donors is discussed in terms of long-range synthon Aufbau modules (LSAMs) and energy frameworks. Dissociations of 2D zigzag chains of parent 4CNpy into 1D dimers observed in its co-crystals are in good agreement with the Aufbau model. Its co-formers, XB donors 1,4-I2(CF2)4, C2I2, 1,3- and 1,4-I2C6F4 (m- and p-DITFB), provide equal energy of I···N XBs, but perfluorinated iodo-alkane 1,4-I2(CF2)4 and diiodoacetylene C2I2 cannot achieve the same strength of homomol. aggregation as π-π stacking in columnar DITFB modules. As a result, DITFBs form I···N XBs with both Npy and NCN nitrogen atoms of 4CNpy, while 1,4-I2(CF2)4 and C2I2 only with the Npy atom. This is not a particular case of 4CNpy co-crystals, but in general, DITFB appears to be a more effective XB donor co-former than C2I2, 1,4-I2(CF2)n and other iodo-XB donors, which has similar potential to an iodine atom but lacks homomol. aggregation. In supramol. reactions of p-DITFB with (η6-Ar)RuX2(4CNpy) (Ar = p-cymene, X = Cl, I) bearing Npy-coordinated 4CNpy, the former gives definite preference to the XBs with the halogen atoms, but not to the CN group of the 4CNpy ligand. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Letters included an article by Chen, Yiyang; Lu, Ping; Wang, Yanguang. Application of 100-48-1. The article was titled 《3-Amino-fluorene-2,4-dicarbonitriles (AFDCs) as Photocatalysts for the Decarboxylative Arylation of α-Amino Acids and α-Oxy Acids with Arylnitriles》. The information in the text is summarized as follows:

1-(4-(9H-Carbazol-9-yl)phenyl)-3-amino-9H-fluorene-2,4-dicarbonitrile as a new photocatalyst for the decarboxylative cross-coupling reaction of α-amino acids or α-oxy carboxylic acids with arylnitriles is described. This light-driven reaction enables a variety of benzylic amines and ethers to be prepared from readily available starting materials under mild conditions. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem