Category: 100-48-1

COA of Formula: C6H4N2In 2020 ,《Nature of the interaction of pyridines with OCS. A theoretical investigation》 appeared in Molecules. The author of the article were Bhattarai, Sumitra; Sutradhar, Dipankar; Chandra, Asit K.; Zeegers-Huyskens, Therese. The article conveys some information:

Ab initio calculations were carried out to investigate the interaction between para-substituted pyridines (X-C5H4N, X = NH2, CH3, H, CN, NO2) and OCS. Three stable structures of pyridine.OCS complexes were detected at the MP2 = full/aug-cc-pVDZ level. The A structure is characterized by N…S chalcogen bonds and has binding energies between -9.58 and -12.24 kJ/mol. The B structure is bonded by N…C tetrel bond and has binding energies between -10.78 and -11.81 kJ/mol. The C structure is characterized by π-interaction and has binding energies between -10.76 and -13.33 kJ/mol. The properties of the systems were analyzed by AIM, NBO, and SAPT calculations The role of the electrostatic potential of the pyridines on the properties of the systems is outlined. The frequency shift of relevant vibrational modes is analyzed. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic Recycling of a Th-H Bond via Single or Double Hydroboration of Inactivated Imines or Nitriles》 were Saha, Sayantani; Eisen, Moris S.. And the article was published in ACS Catalysis in 2019. Quality Control of 4-Cyanopyridine The author mentioned the following in the article:

The catalytic activity of the metallacycle thorium amide [(Me3Si)2N]2Th[κ2-(N,C)-CH2Si(CH3)2N(SiMe3)] (Th1) is presented for the selective dihydroboration of nitriles (-CN) with pinacolborane (HBpin). Using significantly low catalyst loading (0.1 mol %), the dihydroborated amines were achieved by the hydroboration of the -CN triple bond attached with aromatic, aliphatic, and heteroatom backbones with high turnover frequency (TOF) as compared to all the reported homogeneous metal catalysts in this reaction. In addition, for aldimines (-C=N-), the hydroboration precatalyst Th2 has been synthesized by the protonolysis of a seven-membered N-heterocyclic iminato ligand (LH) and Th1. The Th2 crystal structure and its performance in the synthesis of hydroborated secondary amine are also here presented. Detailed kinetic studies and thermodn. and stoichiometric experiments provided us with cumulative evidence supporting the proposed mechanism for the aforementioned reactions. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ACS Catalysis included an article by Betori, Rick C.; Scheidt, Karl A.. Recommanded Product: 100-48-1. The article was titled 《Reductive Arylation of Arylidene Malonates Using Photoredox Catalysis》. The information in the text is summarized as follows:

A strategy with arylidene malonates provides access to β-umpolung single-electron species. Reported here is the utilization of these operators in intermol. radical-radical arylations, while avoiding conjugate addition/dimerization reactivity that is commonly encountered in enone-based photoredox chem. This reactivity relies on tertiary amines that serve to both activate the arylidene malonate for single-electron reduction by a proton-coupled electron transfer mechanism as well as serve as a terminal reductant. This photoredox catalysis pathway demonstrates the versatility of stabilized radicals for unique bond-forming reactions. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100-48-1In 2021 ,《Electroreductive C3 Pyridylation of Quinoxalin-2(1H)-ones: An Effective Way to Access Bidentate Nitrogen Ligandsã€?appeared in Organic Letters. The author of the article were Wen, Jiangwei; Yang, Xiaoting; Yan, Kelu; Qin, Hongyun; Ma, Jing; Sun, Xuejun; Yang, Jianjing; Wang, Hua. The article conveys some information:

A simple and practical electroreductive-induced C3 pyridylation of quinoxalin-2(1H)-ones with readily available cyanopyridines was reported. More than 36 examples were supplied, and the reaction performed in >95% yield. The present protocol provided a convenient, efficient and gram-scale synthesis strategy for a series of new types of potential bidentate nitrogen ligands I [R = H, Me, F, etc.; R1 = H, Me, Cl; R2 = H, Me, Ph, etc.; R3 = H, Me; R4 = 4-pyridyl, 2-chloro-4-pyridyl, 1-isoquinolyl, etc.; RR1 = CH=CH-CH=CH]. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-CyanopyridineIn 2021 ,《Transition metal-free NaOH-catalyzed hydration of nitriles to primary amides in NH3·H2O-DMSO mixtureã€?appeared in Molecular Diversity. The author of the article were Wang, Nan; Ma, Peilong; Xie, Jianwei; Zhang, Jie. The article conveys some information:

An efficient protocol for hydration of aryl(hetero)/alkyl nitriles RCN (R = Bu, cyclohexyl, thiophen-2-yl, 4-chlorophenyl, etc.) toward primary amides RC(O)NH2 with 0.1 equivalent was reported. NaOH in NH3·H2O-DMSO under mild conditions is used. Various substituted nitriles are smoothly converted to the corresponding amides with good to excellent isolated yields. Gram-scale reactions were also performed to produce the desired products in high yields. In addition, the excessive hydrolysis of the benzonitrile to form benzoic acid was also achieved with increasing the amount of NaOH and prolonging the reaction time. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Jiang, Chenhui; Chen, Yuqin; Gao, Pan; Zhang, Shuwei; Jia, Xiaodong; Yuan, Yu published an article in Organic Letters. The title of the article was 《Direct Transformation of Nitrogen-Containing Methylheteroarenes to Heteroaryl Nitrile by Sodium Nitriteã€?SDS of cas: 100-48-1 The author mentioned the following in the article:

The cyanation reaction of methylheteroarenes with acetyl chloride and sodium nitrite via the radical process in high yields is reported. According to the control experiments, the reaction mechanism underwent radical progress. It is very useful in the pharmacy industry due to its metal-free and easy treatment conditions. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Diacetyl as a “”traceless”” visible light photosensitizer in metal-free cross-dehydrogenative coupling reactionsã€?were Huang, Chia-Yu; Li, Jianbin; Liu, Wenbo; Li, Chao-Jun. And the article was published in Chemical Science in 2019. Reference of 4-Cyanopyridine The author mentioned the following in the article:

Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to sustainability and safety concerns. Herein a new strategy using diacetyl (2,3-butanedione) as an abundant, visible light-sensitive and “”traceless”” hydrogen atom abstractor to achieve metal-free cross-dehydrogenative Minisci alkylation under mild conditions is reported. Mechanistic studies supported hydrogen atom transfer (HAT) between an activated C(sp3)-H substrate and diacetyl. Moreover, with the assistance of di-tert-Bu peroxide (DTBP), the scope of the reaction could be extended to strong aliphatic C-H bonds via diacetyl-mediated energy transfer. The robustness of this strategy was demonstrated by functionalizing complex mols. such as quinine, fasudil, nicotine, menthol and alanine derivatives In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Mediated C-H Alkylation of Pyridine Derivativesã€?was written by Rammal, Fatima; Gao, Di; Boujnah, Sondes; Gaumont, Annie-Claude; Hussein, Aqeel A.; Lakhdar, Sami. Quality Control of 4-CyanopyridineThis research focused onvisible light alkylation pyridine derivative alkane. The article conveys some information:

We report herein a visible-light-mediated C-H alkylation of pyridine derivatives that proceeds by simple combination of a large variety of N-alkoxypyridinium ions with alkanes in the presence of 2 mol % of fac-Ir(ppy)3 under blue illumination. The mild reaction conditions together with the high group functional tolerance make of this process a useful synthetic platform for the construction of structurally strained heterocycles. Detailed mechanistic investigations, including d. functional theory calculations and quantum yield measurement, allowed us to understand factors controlling the reactivity and the selectivity of the reaction. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Diacetyl as a “”traceless”” visible light photosensitizer in metal-free cross-dehydrogenative coupling reactions》 were Huang, Chia-Yu; Li, Jianbin; Liu, Wenbo; Li, Chao-Jun. And the article was published in Chemical Science in 2019. Reference of 4-Cyanopyridine The author mentioned the following in the article:

Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to sustainability and safety concerns. Herein a new strategy using diacetyl (2,3-butanedione) as an abundant, visible light-sensitive and “”traceless”” hydrogen atom abstractor to achieve metal-free cross-dehydrogenative Minisci alkylation under mild conditions is reported. Mechanistic studies supported hydrogen atom transfer (HAT) between an activated C(sp3)-H substrate and diacetyl. Moreover, with the assistance of di-tert-Bu peroxide (DTBP), the scope of the reaction could be extended to strong aliphatic C-H bonds via diacetyl-mediated energy transfer. The robustness of this strategy was demonstrated by functionalizing complex mols. such as quinine, fasudil, nicotine, menthol and alanine derivatives In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H4N2In 2022 ,《Strongly Bound π-Hole Tetrel Bonded Complexes between H2SiO and Substituted Pyridines. Influence of Substituents》 was published in ChemPhysChem. The article was written by Bhattarai, Sumitra; Sutradhar, Dipankar; Chandra, Asit K.. The article contains the following contents:

Ab initio calculation at the MP2/aug-cc-pVTZ level has been performed on the π-hole based N…Si tetrel bonded complexes between substituted pyridines and H2SiO. The primary aim of the study is to find out the effect of substitution on the strength and nature of this tetrel bond, and its similarity/difference with the N…C tetrel bond. Correlation between the strength of the N…Si bond and several mol. properties of the Lewis acid (H2SiO) and base (pyridines) are explored. The properties of the tetrel bond are analyzed using AIM, NBO, and symmetry-adapted perturbation theory calculations The complexes are characterized with short N…Si intermol. distances and high binding energies ranging between -142.72 and -115.37 kJ/mol. The high value of deformation energy indicates significant geometrical distortion of the monomer units. The AIM and NBO anal. reveal significant coordinate covalent bond character of the N…Si π-hole bond. Sharp differences are also noticed in the orbital interactions present in the N…Si and N…C tetrel bonds. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem