Category: 100-48-1

Shen, Jiaxuan; Zhang, Yipin; Yu, Yanjiang; Wang, Manman published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Metal-free visible-light-induced photoredox-catalyzed intermolecular pyridylation/phosphinoylation of alkenes》.Quality Control of 4-Cyanopyridine The article contains the following contents:

Reported here is an intermol. pyridylation/phosphinoylation of alkenes using 4-cyanopyridine and diphenylphosphine oxide under visible-light-induced organic photoredox catalysis. The reaction occurs under mild metal-free conditions, possessing a broad substrate scope. The protocol can be practiced on a gram scale and applied to the modification of natural product-derived and medicinally relevant complex mols. containing a styrene unit. Mechanistic investigations suggest that triethylamine serves as both single-electron transfer (SET) and hydrogen atom transfer (HAT) agents. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H4N2In 2020 ,《Pyridine-Diketopyrrolopyrrole-Based Novel Metal-Free Visible-Light Organophotoredox Catalyst for Atom-Transfer Radical Polymerization》 appeared in Journal of Physical Chemistry A. The author of the article were Yang, Long; Huang, Yujie; Peng, Yuting; Liu, Fei; Zhang, Qingchun; He, Huichao; Wang, Jun; Jiang, Long; Zhou, Yong. The article conveys some information:

In the field of electronics, organocatalysts are in high demand for use in the synthesis of clean polymers using solar radiation rather than potentially contaminating metals. Combining theor. design, simulation, and experiments, this work presents a novel, pyridine-diketopyrrolopyrrole (P-DPP)-based metal-free visible-light organophotoredox catalyst (P-DPP). It is effective in the photocontrolled organocatalytic atom-transfer radical polymerization (O-ATRP) of Me methacrylate (MMA) and styrene. The use of this catalyst and white light-emitting diode (LED) irradiation produces polymers with a crosslinked feature. In O-ATRP, the P-DPP catalyst has an oxidative quenching catalytic mechanism with an excited-state reductive potential of -1.8 V, fluorescence lifetime of 7.5 ns, and radical-cation oxidative potential of 0.45 V. Through mol. simulation, we found that the adjacent pyridine group is key to reducing the alkyl halide initiator and generating radicals, while the diketopyrrolopyrrole core stabilizes the triplet state of the catalyst through intramol. charge transfer. The findings related to this novel photoredox catalyst will aid in the search for much more effective organophotoredox catalysts for use in controlled radical polymerization They will also be of value in the fields of polymer chem. and physics and in various applications. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2021 ,《Nickelocene as an Air- and Moisture-Tolerant Precatalyst in the Regioselective Synthesis of Multisubstituted Pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Cho, Il Young; Kim, Woo Gyum; Jeon, Ji Hwan; Lee, Jeong Woo; Seo, Jeong Kon; Seo, Jongcheol; Hong, Sung You. The article conveys some information:

Herein, operationally simple nickel(0) catalysis to access substituted pyridines I [R = Me, Ph, 2-furyl, etc.; R1 = Me, Ph, trimethylsilyl, etc.; R2 = H, Me, Ph, etc.; Z = CH2, O, C(CO2Et)2, N-Ts] from various nitriles and 1,6-diynes without the aid of air-free techniques was reported. The Ni-Xantphos-based catalytic manifold was tolerant to air, moisture and heat while promoting the [2 + 2 + 2] cycloaddition reactions with high reaction yields and broad substrate scope. In addition, the steric effect but also the frontier MO interactions could played a critical role in determining the regiochem. outcome of nickel-catalyzed [2 + 2 + 2] cycloaddition for the synthesis of compounds I.4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Mechanochemistry, an Easy Technique to Boost the Synthesis of CuI Pyrazine Coordination Polymers》 were Cappuccino, Chiara; Farinella, Francesco; Braga, Dario; Maini, Lucia. And the article was published in Crystal Growth & Design in 2019. SDS of cas: 100-48-1 The author mentioned the following in the article:

Depending on the exptl. conditions, the solid-state reactions of CuI with pyrazine (pyz) yield three distinct coordination polymers (CPs): a double chain polymer [Cu2I2(pyz)]n (yellow powder) and a single strand [CuI(pyz)]n (red powder) and its new isomeric compound [(CuI)2(pyz)2]n (orange powder), which present dimers of CuI bridged by the pyrazine ligands. The conversions among the three CPs were studied: by heating to 110°, [CuI(pyz)]n or [(CuI)2(pyz)2]n convert into [Cu2I2(pyz)]n, which reverts to the starting compounds upon kneading or grinding in the presence of pyrazine. The orange isomer [(CuI)2(pyz)2]n is obtained only when the solid-state reaction is performed with neat grinding or by direct melting of the pyrazine; it is unstable in the presence of solvent or vapor, and it readily transforms into the red isomer. The structure of [(CuI)2(pyz)2]n was determined by x-ray powder diffraction. [Cu2I2(pyz)]n reacts also with 4-cyanopyrazine to yield the mixed ligand compound [(CuI)(4CN-py)2 py]n, which, when heated, decomposes into [Cu2I2(pyz)]n and [(CuI)4(4CN-py)5]n. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 100-48-1In 2020 ,《Halogen bonding interactions in the XC5H4N···YCF3 (X = CH3, H, Cl, CN, NO2; Y = Cl, Br, I) complexes》 appeared in Journal of Molecular Modeling. The author of the article were Sun, Yuanyuan; Shi, Bo; Zhang, Xueying; Zeng, Yanli. The article conveys some information:

The noncovalent interactions between the σ-hole region outside the halogen atom and the nitrogen atom of pyridine and its para-substituted derivatives are the focus of this work. Based on the analyses of the electrostatic potentials, YCF3 (Y = Cl, Br, I) act as halogen bond donors, XC5H4N (X = CH3, H, Cl, CN, NO2) act as halogen bond acceptors, and the binary halogen-bonded complexes XC5H4N···YCF3 have been designed and investigated by B3LYP-D3/aug-cc-pVDZ calculations together with the aug-cc-pVDZ-PP basis set for iodine. When the halogen bond acceptor remains unchanged, the interactions between C5H5N and YCF3 (Y = Cl, Br, I) increase with the order of Y = Cl, Br, and I. When the halogen donor ICF3 is fixed, the halogen bonding interactions decrease along the sequence of X = CH3, H, Cl, CN, NO2. Therefore, the halogen bond of the CH3C5H4N···ICF3 complex is the strongest. The interactions between Lewis acid YCF3 (Y = Cl, Br, I) and pyridine and para-substituted pyridine are closed-shell and noncovalent interactions. On the one hand, when the halogen bond acceptor XC5H4N is fixed, with the increase of halogen at. number, the strength of halogen bond increases; on the other hand, when the halogen bond donor ICF3 is fixed, as the electron-withdrawing ability of the electron-withdrawing group (X) increases, the halogen bond gradually weakens.4-Cyanopyridine(cas: 100-48-1Application of 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction》 were Lipp, Benjamin; Kammer, Lisa Marie; Kuecuekdisli, Murat; Luque, Adriana; Kuehlborn, Jonas; Pusch, Stefan; Matuleviciute, Gita; Schollmeyer, Dieter; Sackus, Algirdas; Opatz, Till. And the article was published in Chemistry – A European Journal in 2019. Recommanded Product: 100-48-1 The author mentioned the following in the article:

Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomols. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Influence of Hydrogen Bonds in 1:1 Complexes of Phosphinic Acids with Substituted Pyridines on 1H and 31P NMR Chemical Shifts》 were Giba, Ivan S.; Mulloyarova, Valeria V.; Denisov, Gleb S.; Tolstoy, Peter M.. And the article was published in Journal of Physical Chemistry A in 2019. Recommanded Product: 100-48-1 The author mentioned the following in the article:

Two series of 1:1 complexes with strong OHN hydrogen bonds formed by dimethylphosphinic and phenylphosphinic acids with 10 substituted pyridines were studied exptl. by liquid state NMR spectroscopy at 100 K in solution in a low-freezing polar aprotic solvent mixture CDF3/CDClF2. The hydrogen bond geometries were estimated using previously established correlations linking 1H NMR chem. shifts of bridging protons with the O···H and H···N interat. distances. A new correlation is proposed allowing one to estimate the interat. distance within the OHN bridge from the displacement of 31P NMR signal upon complexation. We show that the values of 31P NMR chem. shifts are affected by an addnl. CH···O hydrogen bond formed between the P=O group of the acid and ortho-CH proton of the substituted pyridines. Breaking of this bond in the case of 2,6-disubstituted bases shifts the 31P NMR signal by ca. 1.5 ppm to the high field. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Recommanded Product: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-CyanopyridineIn 2022 ,《Electrochemical Ammonium Cation-Assisted Hydropyridylation of Ketone-Activated Alkenes: Experimental and Computational Mechanistic Studies》 appeared in Advanced Synthesis & Catalysis. The author of the article were Yang, Jianjing; Ma, Jing; Yan, Kelu; Tian, Laijin; Li, Bingwen; Wen, Jiangwei. The article conveys some information:

This work described an electrochem. ammonium cation enabled hydropyridylation of ketone-activated alkenes under metal- and exogenous reductant free conditions giving access to β-pyridyl ketones, through dual proton-coupled electron transfer and radical cross-coupling. It featured a broad substrate scope and allows a gram-scale synthesis. Ammonium chloride played various roles in this transformation such as the hydrogen donor, the protonation reagent and electrolyte. In particular, various experiments and d. functional theory (DFT) calculation results showed the mechanism of dual proton-coupled electron transfer followed by radical cross-coupling was the preferred pathway.4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 100-48-1In 2019 ,《New insights on the electronic, magnetic, electric and molecular structure of a bis-(4-cyanopyridine) iron(III) complex with the meso-tetrakis(4-methoxyphenyl)porphyrin》 appeared in Inorganica Chimica Acta. The author of the article were Ben Haj Hassen, Leila; Dhifaoui, Selma; Rousselin, Yoann; Marvaud, Valerie; Stern, Christine; Schulz, Charles E.; Nasri, Habib. The article conveys some information:

The authors have successfully synthesized and characterized a new low-spin iron(III) bis(4-cyanopyridine) complex with a meso-porphyrin substituted in the para positions of the phenyls by the methoxy group, namely the bis(4-cyanopyridine)[meso-tetrakis(4-metoxyphenylporphyrinato)]iron(III) trifluoromethanesulfonate chlorobenzene monosolvate complex with the formula [FeIII(TMPP)(4-CNpy)2]SO3CF3.C6H5Cl(1). This species was characterized through UV-visible, FTIR and Mossbauer spectroscopy as well as by SQUID magnetometry, cyclic voltammetry, and x-ray crystallog. These characterizations indicated that the authors’ synthetic heme model is a low-spin (S = 1/2) coordination compound and especially shows that the structural, electronic and the magnetic properties of complex (1) are closely dominated by the presence of the methoxy σ-donor group at the para positions of the meso-porphyrin. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation》 was published in Chemistry – A European Journal in 2020. These research results belong to Formenti, Dario; Mocci, Rita; Atia, Hanan; Dastgir, Sarim; Anwar, Muhammad; Bachmann, Stephan; Scalone, Michelangelo; Junge, Kathrin; Beller, Matthias. Synthetic Route of C6H4N2 The article mentions the following:

Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700°C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.g. 70°C, 20 bar H2). The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested com. catalysts, for example, Raney Nickel and even noble-metal-based systems in these transformations. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Synthetic Route of C6H4N2) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Synthetic Route of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem