Category: 100-48-1

Quality Control of 4-CyanopyridineIn 2019 ,《Direct Arylation of α-Amino C(sp3)-H Bonds by Convergent Paired Electrolysis》 was published in Angewandte Chemie, International Edition. The article was written by Ma, Yueyue; Yao, Xiantong; Zhang, Lei; Ni, Pufan; Cheng, Ruihua; Ye, Jinxing. The article contains the following contents:

A metal-free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives at room temperature was developed. This TEMPO-mediated electrocatalytic reaction made full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, thus showing great potential and advantages for practical synthesis. This convergent paired electrolysis method provided a straightforward and powerful means to activate C-H bonds and realize cross-coupling with cathodically generated species. The experimental process involved the reaction of 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Millimeter-wave spectrum of 4-cyanopyridine in its ground state and lowest-energy vibrationally excited states, ν20 and ν30》 was published in Journal of Molecular Spectroscopy in 2020. These research results belong to Dorman, P. Matisha; Esselman, Brian J.; Park, Jieun E.; Woods, R. Claude; McMahon, Robert J.. Category: pyridine-derivatives The article mentions the following:

The rotational spectrum of 4-cyanopyridine (μa = 1.96 D) was recorded from 130 to 360 GHz, and the anal. of the ground state and two lowest-energy excited vibrational states was completed. Over 3900 new rotational transitions were measured for the ground state, allowing the determination of spectroscopic constants for a partial octic, distorted-rotor Hamiltonian. Over 5600 new transitions were measured for the Coriolis-coupled dyad, ν20 and ν30. A coupled-state least-squares fit of the dyad was obtained, which resulted in the precise determination of several parameters addressing the Coriolis coupling between the two states: Ga, GJa, Fbc, and FKbc. With inclusion of these terms, numerous resonance transitions associated with selection rules ΔKa = 2 or ΔKa = 4 between vibrational states were assigned and fit to low error (σfit < 50 kHz). The precise energy difference between ν20 and ν30 was determined, ΔE = 18.806554 (11) cm-1, along with the Coriolis coupling coefficient ζa20,30 = 0.8432 (8). Determination of the spectroscopic and perturbation parameters for the vibrational states permits comparison to other arenes bearing -CN or -NC substituents and sharing a similar Coriolis-coupled dyad ∼150 cm-1 above the ground state. This new data provides the foundation for an astrochem. search for 4-cyanopyridine in the interstellar medium. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Category: pyridine-derivatives)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Excited-State Quenching of Porphyrins by Hydrogen-Bonded Phenol-Pyridine Pair: Evidence of Proton-Coupled Electron Transfer》 were Venkatesan, Munisamy; Mandal, Haraprasad; Chakali, Madhu; Bangal, Prakriti Ranjan. And the article was published in Journal of Physical Chemistry C in 2019. Synthetic Route of C6H4N2 The author mentioned the following in the article:

A series of porphyrins containing methoxy-substituted phenols were treated with different pyridine bases. Besides hydrogen bonding (H-bonding), the pyridine bases have imparted oxidation to the phenol rings resulting in coupled electron and proton movement. It has been shown that reduction of an excited substrate/porphyrin macrocycle by phenols with adjacent methoxy groups is facilitated by the movement or transfer of the phenolic proton toward H-bonded bases. Rates of electron transfer are accomplished by associated proton displacements within the redox reaction complex. Demonstrated fluorescence quenching of meso-(4-hydroxyphenyl derivatives)-substituted porphyrins in aprotic solvents is attributed to electron transfer from the phenol moiety by added bases (different pyridine derivatives), and rates of quenching are found to be correlated with Brönsted base strength rather than H-bonding equilibrium The rate of quenching is observed to be a function of the extent of hydroxy and methoxy substitutions to the phenyls and the solvent polarities. Replacement of 4-hydroxy by 4-methoxy completely eliminated the quenching indicating the disappearance of reduction in the porphyrin macrocycle. The dependence of the extent of fluorescence quenching of studied porphyrins on pyridine concentration led to phenol-pyridine H-bonding equilibrium constants, and these values closely resemble the values obtained directly from the corresponding absorption spectra. The quenching agent is thus revealed to be H-bonded phenol. Further, pos. deuterium isotope effects on quenching upon deuteration of the hydroxyl confirm that the electron transfer is coupled to the proton movement. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Synthetic Route of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-CyanopyridineIn 2019 ,《Reactivity of Selected Mono- and Dimethylpyridines under Conditions of Oxidative Ammonolysis》 appeared in Russian Journal of General Chemistry. The author of the article were Vorobyev, P. B.; Serebryanskaya, A. P.. The article conveys some information:

The reactivity of 3-methyl-, 4-methyl-, 2,3-dimethyl-, and 3,4-dimethylpyridines under the oxidative ammonolysis on vanadium oxide catalysts has been studied. The yield of monocyanopyridines has been related to the simulated values of the deprotonation enthalpy of Me substituents being converted into the cyano group, both in the gas phase and under conditions simulating chemisorption at the acid center of the catalyst. Differences in the mechanism of conversion of the primary products of oxidative ammonolysis of 2,3- and 3,4-dimethylpyridines (2-cyano-3-methyl- and 4-cyano-3-methylpyridines) at elevated temperature have been revealed. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-48-1In 2021 ,《Mechanochemical Release of Non-Covalently Bound Guests from a Polymer-Decorated Supramolecular Cage》 appeared in Angewandte Chemie, International Edition. The author of the article were Kueng, Robin; Pausch, Tobias; Rasch, Dustin; Goestl, Robert; Schmidt, Bernd M.. The article conveys some information:

Supramol. coordination cages show a wide range of useful properties including, but not limited to, complex mol. machine-like operations, confined space catalysis, and rich host-guest chemistries. Here we report the uptake and release of non-covalently encapsulated, pharmaceutically-active cargo from an octahedral Pd cage bearing polymer chains on each vertex. Six poly(ethylene glycol)-decorated bipyridine ligands are used to assemble an octahedral PdII6(TPT)4 cage. The supramol. container encapsulates progesterone and ibuprofen within its hydrophobic nanocavity and is activated by shear force produced by ultrasonication in aqueous solution entailing complete cargo release upon rupture, as shown by NMR and GPC analyses. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Related Products of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Sheng; Li, Lijun; Li, Jingjing; Shi, Jianxue; Xu, Kun; Gao, Wenchao; Zong, Luyi; Li, Guigen; Findlater, Michael published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis》.Electric Literature of C6H4N2 The article contains the following contents:

Arylation of carbonyls, one of the most common approaches toward alcs., has received tremendous attention, as alcs. are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochem. arylation can fill the gap. By taking advantage of synthetic electrochem., com. available aldehydes (ketones) and benzylic alcs. can be readily arylated to provide a general and scalable access to structurally diverse alcs. (97 examples, >10 g-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochem. technol., was employed to transform low-value alcs. into more useful alcs. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral α-arylation of benzylic alcs. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Electric Literature of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate》 was published in Journal of the American Chemical Society in 2020. These research results belong to Sato, Yukiya; Nakamura, Kei; Sumida, Yuto; Hashizume, Daisuke; Hosoya, Takamitsu; Ohmiya, Hirohisa. Safety of 4-Cyanopyridine The article mentions the following:

The generation of tertiary, secondary, and primary alkyl radicals has been achieved by the direct visible-light excitation of a boracene-based alkylborate. This system is based on the photophys. properties of the organoboron mol. The protocol is applicable to decyanoalkylation, Giese addition, and nickel-catalyzed carbon-carbon bond formations such as alkyl-aryl cross-coupling or vicinal alkylarylation of alkenes, enabling the introduction of various C(sp3) fragments to organic mols. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Electrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer》 was written by Lehnherr, Dan; Lam, Yu-hong; Nicastri, Michael C.; Liu, Jinchu; Newman, Justin A.; Regalado, Erik L.; DiRocco, Daniel A.; Rovis, Tomislav. SDS of cas: 100-48-1 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Accessing hindered amines, particularly primary amines α to a fully substituted carbon center, is synthetically challenging. We report an electrochem. method to access such hindered amines starting from benchtop-stable iminium salts and cyanoheteroarenes. A wide variety of substituted heterocycles (pyridine, pyrimidine, pyrazine, purine, azaindole) can be utilized in the cross-coupling reaction, including those substituted with a halide, trifluoromethyl, ester, amide, or ether group, a heterocycle, or an unprotected alc. or alkyne. Mechanistic insight based on DFT data, as well as cyclic voltammetry and NMR spectroscopy, suggests that a proton-coupled electron-transfer mechanism is operational as part of a hetero-biradical cross-coupling of α-amino radicals and radicals derived from cyanoheteroarenes. Safety: cyanide may be released as a byproduct leading to release of toxic HCN. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghosh, Pradip; Jacobi von Wangelin, Axel published an article in 2021. The article was titled 《Manganese-Catalyzed Hydroborations with Broad Scope》, and you may find the article in Angewandte Chemie, International Edition.Reference of 4-Cyanopyridine The information in the text is summarized as follows:

Reductive transformations of easily available oxidized matter are at the heart of synthetic manipulation and chem. valorization. The applications of catalytic hydrofunctionalization benefit from the use of liquid reducing agents and operationally facile setups. Metal-catalyzed hydroborations provide a highly prolific platform for reductive valorizations of stable C:X electrophiles. Here, the authors report an especially facile, broad-scope reduction of various functions including carbonyls, carboxylates, pyridines, carbodiimides, and carbonates under very mild conditions with the inexpensive pre-catalyst Mn(hmds)2. The reaction could be successfully applied to depolymerizations In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Enabled Ortho-Selective Aminopyridylation of Alkenes with N-Aminopyridinium Ylides》 was published in Journal of the American Chemical Society in 2020. These research results belong to Moon, Yonghoon; Lee, Wooseok; Hong, Sungwoo. COA of Formula: C6H4N2 The article mentions the following:

By utilizing an underexplored reactivity mode of N-aminopyridinium ylides, we developed the visible-light-induced ortho-selective aminopyridylation of alkenes via radical-mediated 1,3-dipolar cycloaddition The photocatalyzed single-electron oxidation of N-aminopyridinium ylides generates the corresponding radical cations that enable previously inaccessible 1,3-cycloaddition with a broader range of alkene substrates. The resulting cycloaddition adducts rapidly undergo subsequent homolytic cleavage of the N-N bond, conferring a substantial thermodn. driving force to yield various β-aminoethylpyridines. Remarkably, amino and pyridyl groups can be installed into both activated and unactivated alkenes with modular control of ortho-selectivity and 1,2-syn-diastereoselectivity under metal-free and mild conditions. Combined exptl. and computational studies are conducted to clarify the detailed reaction mechanism and the origins of site selectivity and diastereoselectivity. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem