Category: 100-54-9

Electric Literature of C6H4N2《Switching Selectivity in Copper-Catalyzed Transfer Hydrogenation of Nitriles to Primary Amine-Boranes and Secondary Amines under Mild Conditions》 was published in 2022. The authors were Song, Hao;Xiao, Yao;Zhang, Zhuohua;Xiong, Wanjin;Wang, Ren;Guo, Liangcheng;Zhou, Taigang, and the article was included in《Journal of Organic Chemistry》. The author mentioned the following in the article:

A simple and efficient copper-catalyzed selective transfer hydrogenation of nitriles to primary amine-boranes I [R = n-Bu, Ph, cyclohexyl, etc.] and secondary amines R¹CH(R²)NHCH₂R³ [R¹ = Ph, 2-furyl, 1-naphthyl, etc.; R² = H, Me; R³ = Ph, 4-MeC₆H₄, 3-thienyl, etc.] with an oxazaborolidine-BH₃ complex was reported. The selectivity control was achieved under mild conditions by switching the solvent and the copper catalysts. More than 30 primary amine-boranes and 40 secondary amines were synthesized via this strategy in high selectivity and yields of up to 95%. The strategy was applied to the synthesis of ¹⁵N labeled in 89% yield.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Electric Literature of C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 3-Cyanopyridine《Site-Selective 1,4-Difunctionalization of Nitrogen Heteroaromatics for Constructing Vinylidene Heterocycles》 was published in 2022. The authors were He, Qianlin;Zhong, Mingli;Chen, Zhichao;Liao, Chuyi;Xie, Feng;Zhu, Zhongzhi;Chen, Xiuwen, and the article was included in《Advanced Synthesis & Catalysis》. The author mentioned the following in the article:

A one-pot protocol for constructing 1,4-difunctionalized quinoline/pyridine derivatives via the reaction of N-heteroaromatics, alkyl halides, and active methylene/methyl compounds was developed. The transformation involves dearomative functionalization of an in situ-activated N-heteroaromatic to construct new C-N and C=C bonds. This reaction has a broad substrate scope and functional group tolerance. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Safety of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 3-Cyanopyridine《Decarbonylative Synthesis of Aryl Nitriles from Aromatic Esters and Organocyanides by a Nickel Catalyst》 was published in 2021. The authors were Iizumi, Keiichiro;Kurosawa, Miki B.;Isshiki, Ryota;Muto, Kei;Yamaguchi, Junichiro, and the article was included in《Synlett》. The author mentioned the following in the article:

A decarbonylative cyanation of aromatic esters with aminoacetonitriles in the presence of a nickel catalyst were developed. The key to this reaction were the use of a thiophene-based diphosphine ligand, dcypt, permitting the synthesis of aryl nitrile without the generation of stoichiometric metal- or halogen-containing chem. wastes. A wide range of aromatic esters, including hetarenes and pharmaceutical mols., were converted into aryl nitriles. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Name: 3-Cyanopyridine This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivatives《Millimeter-Scale Zn(3-ptz)₂ Metal-Organic Framework Single Crystals: Self-Assembly Mechanism and Growth Kinetics》 was published in 2021. The authors were Garcia-Garfido, Juan M.;Enriquez, Javier;Chi-Duran, Ignacio;Jara, Ivan;Vivas, Leonardo;Hernandez, Federico J.;Herrera, Felipe;Singh, Dinesh P., and the article was included in《ACS Omega》. The author mentioned the following in the article:

The solvothermal synthesis of metal-organic frameworks (MOFs) often proceeds through competing crystallization pathways, and only partial control over the crystal nucleation and growth rates is possible. It challenges the use of MOFs as functional devices in free-space optics, where bulk single crystals of millimeter dimensions and high optical quality are needed. We develop a synthetic protocol to control the solvothermal growth of the MOF [Zn(3-ptz)₂]_n (MIRO-101), to obtain large single crystals with projected surface areas of up to 25 mm² in 24 h, in a single reaction with in situ ligand formation. No addnl. cooling and growth steps are necessary. We propose a viable reaction mechanism for the formation of MIRO-101 crystals under acidic conditions, by isolating intermediate crystal structures that directly connect with the target MOF and reversibly interconverting between them. We also study the nucleation and growth kinetics of MIRO-101 using ex situ crystal image anal. The synthesis parameters that control the size and morphol. of our target MOF crystal are discussed. Our work deepens our understanding of MOF growth processes in solution and demonstrates the possibility of building MOF-based devices for future applications in optics. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Category: pyridine-derivatives It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3-CyanopyridineIn 2022, Zhu, Daoyun;Liu, Haiou;Huang, Yangqiang;Luo, Xiao;Mao, Yu;Liang, Zhiwu published 《Study of Direct Synthesis of DMC from CO₂ and Methanol on CeO₂: Theoretical Calculation and Experiment》. 《Industrial & Engineering Chemistry Research》published the findings. The article contains the following contents:

Rare earth metal oxides are known to have good catalytic effectiveness in the direct synthesis of di-Me carbonate (DMC) from CO₂ and methanol. In this work, we screened ceria (CeO₂) catalysts by analyzing their capacity for CO₂ adsorption. The effects of the crystal surface morphol. and oxygen vacancy on the catalytic performance of the ceria catalyst were studied by using d. functional theory (DFT). The results show that the (110) surface and higher oxygen vacancy content can better promote the synthesis of DMC and that the rod-shaped CeO₂ catalyst has a better catalytic effect. The oxygen vacancy content on the catalyst was improved by freeze-drying and confirmed by thermogravimetric anal., Raman spectroscopy, and ESR. The freeze-dried CeO₂ (CeO₂-FD) then showed a higher catalytic performance. The conversion rate of methanol and the yield of DMC were 33.95% and 584 mmol g^-1cat, resp., under mild conditions (140°C and 1 MPa). The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Recommanded Product: 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2022, Zheng, Shixin;Wang, Dong;Huang, Mindong;Yu, Peng published 《Rapid Generation of Tetrahydropyridines and Tetrahydroquinolines by Dearomative Cyanation/Grignard Addition》. 《Chemistry – An Asian Journal》published the findings. The article contains the following contents:

A rapid, practical and scalable method for the reductant and tansition-metal-free synthesis of a variety of novel 2,4-disubstituted tetrahydropyridines and tetrahydroquinolines was disclosed. The method was based upon dearomative functionalization of pyridines or quinolines to generate amino nitrile intermediates as masked iminium ions, which then react rapidly with various Grignard reagents in complete stereocontrol. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivatives《Energetically significant nitrile···nitrile and unconventional C-H···π(nitrile) interactions in pyridine based Ni(II) and Zn(II) coordination compounds: Antiproliferative evaluation and theoretical studies》 was published in 2021. The authors were Das, Amal;Sharma, Pranay;Frontera, Antonio;Verma, Akalesh K.;Barcelo-Oliver, Miquel;Hussain, Sahid;Bhattacharyya, Manjit K., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

Two new coordination compounds viz. [Ni(2,6-PDC)(Hdmpz)(H₂O)₂]•H₂O (1) and [Zn(3-CNpy)₂Cl₂] (2) (2,6-PDC = 2,6-pyridinedicarboxylate, Hdmpz = 3,5-dimethylpyrazole, 3-CNpy = 3-cyanopyridine) were synthesized and characterized using elemental anal., TGA, electronic, IR spectroscopy and single crystal x-ray diffraction techniques. Crystal structure analyses reveal supramol. assemblies involving interesting dimers with unconventional contacts in the compounds DFT (D. Functional Theory) calculations on the supramol. dimers in the crystal structure of 1 reveal that the sum of contributions of anion-π, π-π and other long range interactions due to the approximation of the bulk monomers is energetically significant. Mol. Electrostatic Potential (MEP) surface and Quantum Theory of Atoms in Mols. (QTAIM) analyses on the interesting supramol. dimers of the crystal structures of 2 reveal unconventional anion···π contacts involving coordinated chlorido ligands and C-H···π(nitrile) interactions involving the π-system of the nitrile moiety of 3-cyanopyridine. Remarkably, Atoms in Mols. anal. also confirms the existence of energetically significant unconventional anti-parallel nitrile···nitrile interaction in the crystal structure of 2. Cell cytotoxicity of the compounds performed in Da’s lymphoma (DL) malignant cancer cell line showed effective potency with negligible cytotoxicity in normal cells (∼12%). Compound 1 has excellent cytotoxic potency with IC₅₀ closer to cisplatin and can bind different biol. targets with similar signaling pathways. Structure activity relation (SAR) analyses of 1 and 2 based on pharmacophore modeling reveal that the mol. features associated with the structures of the compounds play important role in the biol. activities. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Category: pyridine-derivatives It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fan, Weibin;Zhang, Yuan;Li, Yinghua;Zhang, Wei;Huang, Deguang published 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》 in 2022. The article was appeared in 《ChemSusChem》. They have made some progress in their research.Quality Control of 3-Cyanopyridine The article mentions the following:

A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R¹ = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R² = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R¹ = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R² = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lecroq, William;Schleinitz, Jules;Billoue, Mallaury;Perfetto, Anna;Gaumont, Annie-Claude;Lalevee, Jacques;Ciofini, Ilaria;Grimaud, Laurence;Lakhdar, Sami published 《Metal-Free Deoxygenation of Amine N-Oxides: Synthetic and Mechanistic Studies》. The research results were published in《ChemPhysChem》 in 2021.Computed Properties of C6H4N2 The article conveys some information:

An unprecedented combination of light and P(III)/P(V) redox cycling for the efficient deoxygenation of aromatic amine N-oxides was reported. Moreover, a large variety of aliphatic amine N-oxides was easily deoxygenated by using only phenylsilane. These practically simple approaches proceeded well under metal-free conditions, tolerated many functionalities and were highly chemoselective. Combined exptl. and computational studies enabled a deep understanding of factors controlling the reactivity of both aromatic and aliphatic amine N-oxides. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Computed Properties of C6H4N2

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 100-54-9《Proximity Effect in Uranyl Coordination of the Cucurbit[6]uril-Bipyridinium Pseudorotaxane Ligand for Promoting Host-Guest Synergistic Chelating》 was published in 2021. The authors were Li, Fei-ze;Geng, Jun-shan;Hu, Kong-qiu;Yu, Ji-pan;Liu, Ning;Chai, Zhi-fang;Mei, Lei;Shi, Wei-qun, and the article was included in《Inorganic Chemistry》. The author mentioned the following in the article:

The authors proposed regulating uranyl coordination behavior of cucurbituril-bipyridinium pseudorotaxane ligand by using meta-functionalized bipyridinium dicarboxylate guest. A tailored pseudorotaxane precursor involving 1,1′-(hexane-1,6-diyl)bis(3-cyanopyridin-1-ium) bromide (C6BPCN3) and cucurbit[6]uril (CB[6]) has been designed and synthesized. Through in situ hydrolysis of the pseudorotaxane ligands and their coordination assembly with uranyl cations, seven new uranyl-rotaxane coordination polymers URCP1-URCP7 were obtained under hydrothermal conditions in the presence of different anions. The variation of carboxylate groups from para- to meta-position affected the coordination of the meta-functionalized pseudorotaxane linkers, which are enriched from simple guest-only binding to host-guest simultaneous coordination and synergistic chelating. This effective regulation on uranyl coordination of supramol. pseudorotaxane can be attributed to the proximity effect, which refers to the meta-position carboxyl group being spatially closer to the portal carbonyl group of CB[6]. Also, by combining other regulation methods such as introducing competing counterions and modulating solution acidity, the nuclearity of the uranyl center and the coordination patterns of the pseudorotaxane ligand can be diversely tuned, which subsequently exert great influence on the final dimensionality of resultant uranyl compounds This work presents a large diversity of uranyl-based coordination polyrotaxane compounds with fascinating mech. interlocked components and, most importantly, provides a feasible approach to adjust and control the metal coordination behavior of the pseudorotaxane ligand that might expand the scope of application of such supramol. ligands.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.Product Details of 100-54-9 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem